ID   TONB_KLEPN              Reviewed;         243 AA.
AC   P45610;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Protein TonB;
GN   Name=tonB;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1033-5P14 / KAY2026;
RX   PubMed=8370545; DOI=10.1016/0378-1119(93)90663-n;
RA   Bruske A., Anton M., Heller K.J.;
RT   "Cloning and sequencing of the Klebsiella pneumoniae tonB gene and
RT   characterization of Escherichia coli-K. pneumoniae TonB hybrid proteins.";
RL   Gene 131:9-16(1993).
CC   -!- FUNCTION: Interacts with outer membrane receptor proteins that carry
CC       out high-affinity binding and energy dependent uptake into the
CC       periplasmic space of specific substrates. It could act to transduce
CC       energy from the cytoplasmic membrane to specific energy-requiring
CC       processes in the outer membrane, resulting in the release into the
CC       periplasm of ligands bound by these outer membrane proteins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Forms a complex with the accessory proteins ExbB
CC       and ExbD (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein; Periplasmic side.
CC   -!- SIMILARITY: Belongs to the TonB family. {ECO:0000305}.
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DR   EMBL; X68478; CAA48498.1; -; Genomic_DNA.
DR   PIR; JN0788; JN0788.
DR   AlphaFoldDB; P45610; -.
DR   SMR; P45610; -.
DR   PHI-base; PHI:6651; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031992; F:energy transducer activity; IEA:InterPro.
DR   GO; GO:0015343; F:siderophore transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003538; TonB.
DR   InterPro; IPR006260; TonB/TolA_C.
DR   InterPro; IPR037682; TonB_C.
DR   Pfam; PF03544; TonB_C; 1.
DR   PRINTS; PR01374; TONBPROTEIN.
DR   TIGRFAMs; TIGR01352; tonB_Cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport; Repeat;
KW   Signal-anchor; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..243
FT                   /note="Protein TonB"
FT                   /id="PRO_0000196200"
FT   TOPO_DOM        1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..30
FT                   /note="Helical; Signal-anchor"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..243
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          69..70
FT                   /note="1-1"
FT   REPEAT          71..72
FT                   /note="1-2"
FT   REPEAT          73..74
FT                   /note="1-3"
FT   REPEAT          75..76
FT                   /note="1-4"
FT   REPEAT          77..78
FT                   /note="1-5; approximate"
FT   REPEAT          79..80
FT                   /note="1-6; approximate"
FT   REPEAT          81..82
FT                   /note="1-7"
FT   REPEAT          91..92
FT                   /note="2-1"
FT   REPEAT          93..94
FT                   /note="2-2; approximate"
FT   REPEAT          95..96
FT                   /note="2-3"
FT   REPEAT          97..98
FT                   /note="2-4"
FT   REPEAT          99..100
FT                   /note="2-5"
FT   REPEAT          101..102
FT                   /note="2-6"
FT   REPEAT          103..104
FT                   /note="2-7"
FT   REPEAT          105..106
FT                   /note="2-8"
FT   REGION          53..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..82
FT                   /note="7 X 2 AA approximate tandem repeats of E-P"
FT   REGION          91..106
FT                   /note="8 X 2 AA approximate tandem repeats of K-P"
FT   COMPBIAS        55..69
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..95
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   243 AA;  26613 MW;  F9583BBDF6015ADC CRC64;
     MTLDLPRRFP WPTLLSVAIH GAVVAGLLYT SVHQVIEQPS PTQPIEITMV APADLEPPPA
     QPVVEPVVEP EPEPEPEVVP EPPKEAVVIH KPEPKPKPKP KPKPKPEKKV EQPKREVKPA
     AEPRPASPFE NNNTAPARTA PSTSTAAAKP TVTAPSGPRA ISRVQPSYPA RAQALRIEGT
     VRVKFDVSPD GRIDNLQILS AQPANMFERE VKSAMRRWRY QQGRPGTGVT MTIKFRLNGV
     EIN