ID   TONB_NEIMB              Reviewed;         280 AA.
AC   P57004;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Protein TonB;
GN   Name=tonB; OrderedLocusNames=NMB1730;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: Interacts with outer membrane receptor proteins that carry
CC       out high-affinity binding and energy dependent uptake into the
CC       periplasmic space of specific substrates. It could act to transduce
CC       energy from the cytoplasmic membrane to specific energy-requiring
CC       processes in the outer membrane, resulting in the release into the
CC       periplasm of ligands bound by these outer membrane proteins. Required
CC       for heme utilization and virulence.
CC   -!- SUBUNIT: The accessory proteins ExbB and ExbD seem to form a complex
CC       with TonB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE002098; AAF42075.1; -; Genomic_DNA.
DR   PIR; A81049; A81049.
DR   RefSeq; NP_274733.1; NC_003112.2.
DR   RefSeq; WP_002212590.1; NC_003112.2.
DR   AlphaFoldDB; P57004; -.
DR   SMR; P57004; -.
DR   STRING; 122586.NMB1730; -.
DR   PaxDb; P57004; -.
DR   EnsemblBacteria; AAF42075; AAF42075; NMB1730.
DR   KEGG; nme:NMB1730; -.
DR   PATRIC; fig|122586.8.peg.2217; -.
DR   HOGENOM; CLU_899630_0_0_4; -.
DR   OMA; DCYLHLK; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR   GO; GO:0031992; F:energy transducer activity; IBA:GO_Central.
DR   GO; GO:0015343; F:siderophore transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003538; TonB.
DR   InterPro; IPR006260; TonB/TolA_C.
DR   InterPro; IPR037682; TonB_C.
DR   Pfam; PF03544; TonB_C; 1.
DR   PRINTS; PR01374; TONBPROTEIN.
DR   TIGRFAMs; TIGR01352; tonB_Cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Transport; Virulence.
FT   CHAIN           1..280
FT                   /note="Protein TonB"
FT                   /id="PRO_0000196203"
FT   TOPO_DOM        1..5
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..27
FT                   /note="Helical; Signal-anchor"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..280
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          51..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..83
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  29199 MW;  DF82E3A9C4A16A9A CRC64;
     MDKERILTPA VVFSVALLHL AMVALLWQAH KLPVIESGNV IEFVDLGDFG GGDGAPEGAG
     APAAPEPQPV PEPPKPVEPP KPVLKPVVTK KADADIQQPK EEPKPEEKPK PEEKPKPEPK
     PEAKPVPKPA EKPVEKPSEK PAEHPGNASA KADSEQGNGE DKGTGTKGDG TGRGEGSGKG
     SGGVKGEHGE GAGSSKGNPL RANGSIPRPA YPTLSMENDE QGTVVLSVLV SPGGHVESVK
     IVKSSGFSRL DNAARKAAQN GHFQANAWTE FKVPVKFELN