ID   TONB_NEIMC              Reviewed;         278 AA.
AC   P95374;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protein TonB;
GN   Name=tonB;
OS   Neisseria meningitidis serogroup C.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=135720;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=8013.6 / Serogroup C;
RX   PubMed=9006036; DOI=10.1128/jb.179.3.805-812.1997;
RA   Stojiljkovic I., Srinivasan N.;
RT   "Neisseria meningitidis tonB, exbB, and exbD genes: Ton-dependent
RT   utilization of protein-bound iron in Neisseriae.";
RL   J. Bacteriol. 179:805-812(1997).
CC   -!- FUNCTION: Interacts with outer membrane receptor proteins that carry
CC       out high-affinity binding and energy dependent uptake into the
CC       periplasmic space of specific substrates. It could act to transduce
CC       energy from the cytoplasmic membrane to specific energy-requiring
CC       processes in the outer membrane, resulting in the release into the
CC       periplasm of ligands bound by these outer membrane proteins. Required
CC       for heme utilization and virulence.
CC   -!- SUBUNIT: The accessory proteins ExbB and ExbD seem to form a complex
CC       with TonB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB family. {ECO:0000305}.
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DR   EMBL; U77738; AAC44834.1; -; Genomic_DNA.
DR   AlphaFoldDB; P95374; -.
DR   SMR; P95374; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR006260; TonB/TolA_C.
DR   InterPro; IPR037682; TonB_C.
DR   Pfam; PF03544; TonB_C; 1.
DR   TIGRFAMs; TIGR01352; tonB_Cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Signal-anchor; Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..278
FT                   /note="Protein TonB"
FT                   /id="PRO_0000196204"
FT   TOPO_DOM        1..5
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..27
FT                   /note="Helical; Signal-anchor"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..278
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          51..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..83
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..135
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   278 AA;  29942 MW;  B3D06DC730B5EA26 CRC64;
     MDKERILTPA VVFSVALLHL AMVALLWQAH KLPVIESGNV IEFVDLGDFG GGDGAPEGAG
     APAAPEPQPE PEPPKPVEPP KPVLKPVLRK RRMRIFSSLR KSRNLKKSRN PKKNRNQSLS
     RKRSLSRNRR KNRSRKPSEK PAEHPSNASA KADSEQGNGE ETGTKRDGTG RGEAAVNVSV
     GVKGEHGEGA GSSKGNPLRA NGSIPRPAYP TLSMENDEQG TVVLSVLVSP GGHVESVKIV
     KSSGFSRLDN AARKAAQNGH FQANAWTEFK VPVKFELN