TONB_PSEAE
ID TONB_PSEAE Reviewed; 342 AA.
AC Q51368;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 08-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein TonB;
GN Name=tonB; OrderedLocusNames=PA5531;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=8704984; DOI=10.1099/13500872-142-6-1449;
RA Poole K., Zhao Q., Neshat S., Heinrichs D.E., Dean C.R.;
RT "The Pseudomonas aeruginosa tonB gene encodes a novel TonB protein.";
RL Microbiology 142:1449-1458(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Interacts with outer membrane receptor proteins that carry
CC out high-affinity binding and energy dependent uptake into the
CC periplasmic space of specific substrates. It could act to transduce
CC energy from the cytoplasmic membrane to specific energy-requiring
CC processes in the outer membrane, resulting in the release into the
CC periplasm of ligands bound by these outer membrane proteins (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Forms a complex with the accessory proteins ExbB
CC and ExbD (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TonB family. {ECO:0000305}.
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DR EMBL; U23764; AAB18654.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG08916.1; -; Genomic_DNA.
DR PIR; E82955; E82955.
DR RefSeq; NP_254218.1; NC_002516.2.
DR RefSeq; WP_010895710.1; NZ_QZGE01000012.1.
DR PDB; 6FIP; NMR; -; A=247-342.
DR PDB; 6I97; X-ray; 3.35 A; D/E=251-340.
DR PDBsum; 6FIP; -.
DR PDBsum; 6I97; -.
DR AlphaFoldDB; Q51368; -.
DR BMRB; Q51368; -.
DR SMR; Q51368; -.
DR STRING; 287.DR97_2910; -.
DR PaxDb; Q51368; -.
DR PRIDE; Q51368; -.
DR EnsemblBacteria; AAG08916; AAG08916; PA5531.
DR GeneID; 878138; -.
DR KEGG; pae:PA5531; -.
DR PATRIC; fig|208964.12.peg.5796; -.
DR PseudoCAP; PA5531; -.
DR HOGENOM; CLU_811022_0_0_6; -.
DR InParanoid; Q51368; -.
DR OMA; SEAQAYN; -.
DR BioCyc; PAER208964:G1FZ6-5658-MON; -.
DR PHI-base; PHI:6942; -.
DR PHI-base; PHI:8066; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR GO; GO:0031992; F:energy transducer activity; IBA:GO_Central.
DR GO; GO:0015343; F:siderophore transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071978; P:bacterial-type flagellum-dependent swarming motility; IMP:PseudoCAP.
DR GO; GO:0071236; P:cellular response to antibiotic; IMP:PseudoCAP.
DR GO; GO:0033212; P:iron import into cell; IMP:PseudoCAP.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0044010; P:single-species biofilm formation; IMP:PseudoCAP.
DR GO; GO:0043107; P:type IV pilus-dependent motility; IMP:PseudoCAP.
DR InterPro; IPR003538; TonB.
DR InterPro; IPR006260; TonB/TolA_C.
DR InterPro; IPR037682; TonB_C.
DR Pfam; PF03544; TonB_C; 1.
DR PRINTS; PR01374; TONBPROTEIN.
DR TIGRFAMs; TIGR01352; tonB_Cterm; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Membrane;
KW Protein transport; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..342
FT /note="Protein TonB"
FT /id="PRO_0000196207"
FT TOPO_DOM 1..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..342
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 157..158
FT /note="1"
FT REPEAT 159..160
FT /note="2"
FT REPEAT 161..162
FT /note="3"
FT REPEAT 164..165
FT /note="4"
FT REPEAT 166..167
FT /note="5"
FT REPEAT 168..169
FT /note="6; approximate"
FT REPEAT 170..171
FT /note="7"
FT REPEAT 172..173
FT /note="8"
FT REPEAT 174..175
FT /note="9"
FT REPEAT 176..177
FT /note="10"
FT REPEAT 178..179
FT /note="11"
FT REPEAT 180..181
FT /note="12"
FT REPEAT 190..191
FT /note="13"
FT REPEAT 192..193
FT /note="14"
FT REPEAT 194..195
FT /note="15"
FT REPEAT 196..197
FT /note="16"
FT REPEAT 198..199
FT /note="17"
FT REPEAT 202..203
FT /note="18"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..203
FT /note="18 X 2 approximate repeats of [KE]-P"
FT COMPBIAS 154..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 272
FT /note="G -> R (in Ref. 1; AAB18654)"
FT /evidence="ECO:0000305"
FT STRAND 255..258
FT /evidence="ECO:0007829|PDB:6I97"
FT HELIX 266..269
FT /evidence="ECO:0007829|PDB:6I97"
FT TURN 270..272
FT /evidence="ECO:0007829|PDB:6I97"
FT STRAND 275..283
FT /evidence="ECO:0007829|PDB:6I97"
FT STRAND 287..299
FT /evidence="ECO:0007829|PDB:6I97"
FT HELIX 304..313
FT /evidence="ECO:0007829|PDB:6I97"
FT STRAND 315..317
FT /evidence="ECO:0007829|PDB:6I97"
FT STRAND 322..326
FT /evidence="ECO:0007829|PDB:6I97"
FT STRAND 329..338
FT /evidence="ECO:0007829|PDB:6I97"
SQ SEQUENCE 342 AA; 36892 MW; 157F036B39E9152D CRC64;
MSPQPSRSPD RFSLAALAED HPTAPAQGDE SESLPCVNAQ RGEPNLRVVD CSGARRDEEV
AVEEVLIPYA HGSDPEDVPG EPPKSRWWLS SGAAVAMHVA IIGALVWVMP TPAELNLGHG
ELPKTMQVNF VQLEKKAEPT PQPPAAAPEP TPPKIEEPKP EPPKPKPVEK PKPKPKPKPK
PVENAIPKAK PKPEPKPKPE PEPSTEASSQ PSPSSAAPPP APTVGQSTPG AQTAPSGSQG
PAGLPSGSLN DSDIKPLRMD PPVYPRMAQA RGIEGRVKVL FTITSDGRID DIQVLESVPS
RMFDREVRQA MAKWRFEPRV SGGKIVARQA TKMFFFKIEK RR
