ID   TONB_VIBCH              Reviewed;         244 AA.
AC   O52042; Q9KL38;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Protein TonB;
GN   Name=tonB; OrderedLocusNames=VC_A0910;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Classical CA401;
RX   PubMed=9781885; DOI=10.1046/j.1365-2958.1998.01034.x;
RA   Occhino D.A., Wyckoff E.E., Henderson D.P., Wrona T.J., Payne S.M.;
RT   "Vibrio cholerae iron transport: haem transport genes are linked to one of
RT   two sets of tonB, exbB, exbD genes.";
RL   Mol. Microbiol. 29:1493-1507(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Interacts with outer membrane receptor proteins that carry
CC       out high-affinity binding and energy dependent uptake into the
CC       periplasmic space of specific substrates. It could act to transduce
CC       energy from the cytoplasmic membrane to specific energy-requiring
CC       processes in the outer membrane, resulting in the release into the
CC       periplasm of ligands bound by these outer membrane proteins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Forms a complex with the accessory proteins ExbB
CC       and ExbD (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF96807.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF016580; AAB94544.1; -; Genomic_DNA.
DR   EMBL; AE003853; AAF96807.1; ALT_INIT; Genomic_DNA.
DR   PIR; B82400; B82400.
DR   RefSeq; NP_233295.1; NC_002506.1.
DR   RefSeq; WP_001052693.1; NZ_LT906615.1.
DR   AlphaFoldDB; O52042; -.
DR   SMR; O52042; -.
DR   STRING; 243277.VC_A0910; -.
DR   PRIDE; O52042; -.
DR   DNASU; 2612226; -.
DR   EnsemblBacteria; AAF96807; AAF96807; VC_A0910.
DR   KEGG; vch:VC_A0910; -.
DR   PATRIC; fig|243277.26.peg.3525; -.
DR   eggNOG; COG0810; Bacteria.
DR   HOGENOM; CLU_076057_3_0_6; -.
DR   OMA; FRIFKVP; -.
DR   Proteomes; UP000000584; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR   GO; GO:0031992; F:energy transducer activity; IBA:GO_Central.
DR   GO; GO:0015343; F:siderophore transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003538; TonB.
DR   InterPro; IPR006260; TonB/TolA_C.
DR   InterPro; IPR037682; TonB_C.
DR   Pfam; PF03544; TonB_C; 1.
DR   PRINTS; PR01374; TONBPROTEIN.
DR   TIGRFAMs; TIGR01352; tonB_Cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..244
FT                   /note="Protein TonB"
FT                   /id="PRO_0000196211"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..23
FT                   /note="Helical; Signal-anchor"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..244
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          51..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        66
FT                   /note="P -> L (in Ref. 1; AAB94544)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        88
FT                   /note="K -> E (in Ref. 1; AAB94544)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        125
FT                   /note="T -> M (in Ref. 1; AAB94544)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   244 AA;  26542 MW;  9A8F2D7EEFB828D1 CRC64;
     MNLNRYVIAG GLSLAFHALL LITTDEAQVF AMPAGNPTQS VSINMVSMPK VAPAQPEQTQ
     TEQSKPESVK PTPVQEVVKT PPAKPKVKPH KPKPQTVKKP VPAEQVPSKS VAKPQPEKVE
     RTAETAQKPA PTPNQQPSQP TAASQGITSQ PILVDKPALV SAQVQPRYPR IARKRGIEGT
     VMYEIWLDAQ GNQIKQQLLS SSGTEALDQS ALEAIKQWKF SPHILDGVPV AHRIHIPIRF
     KLEG