ID   TOP1B_OXYTA             Reviewed;          48 AA.
AC   C0HLF5;
DT   16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2019, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=M-oxotoxin-Ot1b {ECO:0000305};
DE            Short=M-OXTX-Ot1b {ECO:0000305};
DE   AltName: Full=Oxyopinin-1b {ECO:0000303|Ref.1};
OS   Oxyopes takobius (Lynx spider) (Oxyopes foliiformis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Oxyopidae; Oxyopes.
OX   NCBI_TaxID=666126;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000269|Ref.1};
RA   Vassilevski A., Grishin E.;
RL   Submitted (SEP-2018) to UniProtKB.
CC   -!- FUNCTION: Disrupts cell membranes, particularly those rich in
CC       phosphocholine, through formation of pores. Has antimicrobial activity,
CC       hemolytic activity and insecticidal activity.
CC       {ECO:0000250|UniProtKB:P83247}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}. Target cell
CC       membrane {ECO:0000250|UniProtKB:P83247}. Note=Forms a transmembrane
CC       alpha-helix in the target cell membrane. Forms a membrane channel in
CC       the prey. {ECO:0000250|UniProtKB:P83247}.
CC   -!- MASS SPECTROMETRY: Mass=5203.1; Mass_error=0.5; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the cationic peptide 02 (oxyopinin-2) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; C0HLF5; -.
DR   SMR; C0HLF5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Hemolysis;
KW   Membrane; Secreted; Target cell membrane; Target membrane; Toxin.
FT   CHAIN           1..48
FT                   /note="M-oxotoxin-Ot1b"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000446061"
SQ   SEQUENCE   48 AA;  5203 MW;  58439CB4D12C9C53 CRC64;
     FRGLAKLLKI GLKSFARVLK KVLPKAAKAG KALAKSLADE NAIRQQNQ