TOP1C_OXYTA
ID TOP1C_OXYTA Reviewed; 48 AA.
AC C0HLF6;
DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2019, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=M-oxotoxin-Ot1c {ECO:0000305};
DE Short=M-OXTX-Ot1c {ECO:0000305};
DE AltName: Full=Oxyopinin-1c {ECO:0000303|Ref.1};
OS Oxyopes takobius (Lynx spider) (Oxyopes foliiformis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Oxyopidae; Oxyopes.
OX NCBI_TaxID=666126;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC TISSUE=Venom {ECO:0000269|Ref.1};
RA Vassilevski A., Grishin E.;
RL Submitted (SEP-2018) to UniProtKB.
CC -!- FUNCTION: Disrupts cell membranes, particularly those rich in
CC phosphocholine, through formation of pores. Has antimicrobial activity,
CC hemolytic activity and insecticidal activity.
CC {ECO:0000250|UniProtKB:P83247}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}. Target cell
CC membrane {ECO:0000250|UniProtKB:P83247}. Note=Forms a transmembrane
CC alpha-helix in the target cell membrane. Forms a membrane channel in
CC the prey. {ECO:0000250|UniProtKB:P83247}.
CC -!- MASS SPECTROMETRY: Mass=5233.1; Mass_error=0.5; Method=MALDI;
CC Evidence={ECO:0000269|Ref.1};
CC -!- SIMILARITY: Belongs to the cationic peptide 02 (oxyopinin-2) family.
CC {ECO:0000305}.
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DR AlphaFoldDB; C0HLF6; -.
DR SMR; C0HLF6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Hemolysis;
KW Membrane; Secreted; Target cell membrane; Target membrane; Toxin.
FT CHAIN 1..48
FT /note="M-oxotoxin-Ot1c"
FT /evidence="ECO:0000269|Ref.1"
FT /id="PRO_0000446062"
SQ SEQUENCE 48 AA; 5233 MW; 464262453E2C9C53 CRC64;
FRGLAKLLKI GLKSFARVLK KILPKAAKAG KSLAKSLADE NAIRQQNQ