ID   TOPZ1_BOVIN             Reviewed;        1653 AA.
AC   G7H7V7;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Protein TOPAZ1 {ECO:0000250|UniProtKB:E5FYH1};
DE   AltName: Full=Testis- and ovary-specific PAZ domain-containing protein 1 {ECO:0000250|UniProtKB:E5FYH1};
GN   Name=TOPAZ1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=22069478; DOI=10.1371/journal.pone.0026950;
RA   Baillet A., Le Bouffant R., Volff J.N., Luangpraseuth A., Poumerol E.,
RA   Thepot D., Pailhoux E., Livera G., Cotinot C., Mandon-Pepin B.;
RT   "TOPAZ1, a novel germ cell-specific expressed gene conserved during
RT   evolution across vertebrates.";
RL   PLoS ONE 6:E26950-E26950(2011).
CC   -!- FUNCTION: Important for normal spermatogenesis and male fertility.
CC       Specifically required for progression to the post-meiotic stages of
CC       spermatocyte development. Seems to be necessary for normal expression
CC       levels of a number of testis-expressed gene transcripts, although its
CC       role in this process is unclear. {ECO:0000250|UniProtKB:E5FYH1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:E5FYH1}.
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DR   EMBL; BK008402; DAA34974.1; -; mRNA.
DR   RefSeq; NP_001239370.1; NM_001252441.1.
DR   AlphaFoldDB; G7H7V7; -.
DR   STRING; 9913.ENSBTAP00000053356; -.
DR   PaxDb; G7H7V7; -.
DR   PRIDE; G7H7V7; -.
DR   Ensembl; ENSBTAT00000061088; ENSBTAP00000053356; ENSBTAG00000044167.
DR   GeneID; 100296400; -.
DR   KEGG; bta:100296400; -.
DR   CTD; 375337; -.
DR   VEuPathDB; HostDB:ENSBTAG00000044167; -.
DR   VGNC; VGNC:36221; TOPAZ1.
DR   eggNOG; ENOG502QPIV; Eukaryota.
DR   GeneTree; ENSGT00390000012495; -.
DR   InParanoid; G7H7V7; -.
DR   OMA; IWVMRES; -.
DR   OrthoDB; 347766at2759; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000044167; Expressed in oocyte and 8 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0098781; P:ncRNA transcription; IEA:Ensembl.
DR   GO; GO:0007286; P:spermatid development; IBA:GO_Central.
DR   GO; GO:0048137; P:spermatocyte division; IBA:GO_Central.
DR   InterPro; IPR038952; TOPAZ1.
DR   InterPro; IPR029435; TOPAZ1_dom.
DR   PANTHER; PTHR35671; PTHR35671; 1.
DR   Pfam; PF14669; Asp_Glu_race_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Differentiation; Reference proteome; Spermatogenesis.
FT   CHAIN           1..1653
FT                   /note="Protein TOPAZ1"
FT                   /id="PRO_0000416056"
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          553..591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          855..893
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          919..942
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        561..583
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        860..881
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        924..942
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1653 AA;  185726 MW;  BEFCDD3D5D975841 CRC64;
     MPRAPPSGPT TAPGREDDAR GLRKRSRRPG LGEAGGCGPE AEGLEESRQK RRMVARASGR
     EEVESDKSAK EKRKVTEASS DDPQPGIDLV RKESLTSSES FPTVECSEFQ SMAFLQSLGK
     ERLVEGIKRR IRIKKCKSLE SPALKMTENK ATQNSKVEFQ DELYKNTLKY SCNSLSPGVE
     NNSVLKLHDC SCLSHSKDCN DENNLAYKPD GGCMHVPENS SKSKKENPRS LIDKTDPSNI
     PQLLQTEENV MRVSQLLLEE NDSYLSKNNG LFSCLQSEKT KHSIEESSIG RKSRKRMKVS
     EKGNGMVIEM KFSNMCNKSE LMLQGNQTGA DGKETEILEA KKSSLKVLRK VNNNTLSPMD
     PLLSLPETGK KTSPEHCANA VFQKALEQLS KEETKNVSQP LGCTSMDPPE DYFKSMKNSL
     VKSLSDCFPI EKRSSRESLK NEAEESKYSC QRTIPMTGKR TWPCYSCARI SAQCWKKASL
     PQSSRQDDFL KHQMNQTHLT DSKLMLQSSV TETNSASSSI EKLDSNLNCL PSVSTVEPTS
     VVIKEPIVND DEKMKSEELS RSASEVVSNT TEDTSLTNMT HNLTGSKKKD RGNLTKLNLT
     VASQDGQEAN NSTSKTVHRK ACITKQALVV PDLVKILNTG RLTNFKIPLL KNKTEKRKEI
     NAKSSEREVY SPLELLDSVS GAEVRQSRTK ENAVTVTSGP QSLSIQRSVI PVQASSDSFC
     SKNSCIIAPS FLKQGNNKQP SNHISASGRI ISNNAAGSLT VENNTFSCDP GCIEKNPTFY
     SNEQEPFKAV SSEVSGRKMT ENFSEIKVGF PDILKAYEDD VLLIDVIQDD PDLFGVSNEG
     ELSFPSEVPM ISQEPNVAEE HQSTDSKHME LPDKKEPSNA LRELPVPDPG SMKSEICASL
     SAASEIKHDS KDANISLGEV THETSSNEKP RGLSEQTKSS DLDEKCRFSD KVAIREEKET
     ISEVCRRDSK NTEIMVGECH LAALVSKPLC LPVPLPPLNL NAHQEDTLLN PQMNDFRLPG
     KHSVLKLQNP EICEIFKREK NVGVFQKPLG LMIPHRYCKF HFNTLRGCER SQCKFGHVPE
     QGDEKVCMDV FKKYISINEL CLLQRAANMF MEYYRKFLPG IHFDLQVLND LLSSLLKHCL
     LKEVFQVMNL CIMIKMLPAL KILLKIFEYV ATMKLRNAVP ALINIFCKLL EAGMVLDPEH
     FNYIVKLLYQ VQASKQEITA VLEMKSRLHM RQFKKNWKCD LEAALNEIEH CKEKGDWTKL
     GNVYLNIKMS CEKFADFQRF CACIAETLTK DCKEERPGVP FCEFAETVSK DLQNSEVDKT
     LLGRIGISAM YFYHKLLQWS KGRKVLDKLY ELKIHFTSLK GLIGPEKLAP RCQIVNIAAE
     IFLKSGSLDG AIWVLRESEW IINTPVWPCD RLDVLNRHNL LCTIAHEILA KSLYRQTFEV
     LQNLPGFQNS QETVEVSQYS LLFNKLLDAC IESNSLGMSS SVAEFMISKS IPIDFSFLRR
     LITSLGRSCL WLKARAHYKS ALSLGCYPPL EGNLYRKLLL IPSYLSEIEM LLAIEIFLVS
     NASSIQSPGT STQMLQIVLK RSEENKSRSK DDYQAAVERL ITAARISDPK LFIKHMTVNV
     NKEQVYSLEQ CSALKWLKEN MKWAGKVWLF NNH