ID   TOPZ1_CALJA             Reviewed;        1695 AA.
AC   F7DF15;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Protein TOPAZ1 {ECO:0000250|UniProtKB:E5FYH1};
DE   AltName: Full=Testis- and ovary-specific PAZ domain-containing protein 1 {ECO:0000250|UniProtKB:E5FYH1};
GN   Name=TOPAZ1;
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important for normal spermatogenesis and male fertility.
CC       Specifically required for progression to the post-meiotic stages of
CC       spermatocyte development. Seems to be necessary for normal expression
CC       levels of a number of testis-expressed gene transcripts, although its
CC       role in this process is unclear. {ECO:0000250|UniProtKB:E5FYH1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:E5FYH1}.
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DR   EMBL; ACFV01038576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01038577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01038578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F7DF15; -.
DR   STRING; 9483.ENSCJAP00000003164; -.
DR   PRIDE; F7DF15; -.
DR   eggNOG; ENOG502QPIV; Eukaryota.
DR   HOGENOM; CLU_003190_0_0_1; -.
DR   InParanoid; F7DF15; -.
DR   OMA; IWVMRES; -.
DR   TreeFam; TF338635; -.
DR   Proteomes; UP000008225; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR038952; TOPAZ1.
DR   InterPro; IPR029435; TOPAZ1_dom.
DR   PANTHER; PTHR35671; PTHR35671; 1.
DR   Pfam; PF14669; Asp_Glu_race_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Differentiation; Reference proteome; Spermatogenesis.
FT   CHAIN           1..1695
FT                   /note="Protein TOPAZ1"
FT                   /id="PRO_0000416057"
FT   REGION          1..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          725..753
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        458..474
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1695 AA;  192059 MW;  C19A4C63E1537D51 CRC64;
     MRRHPPLDPT MAPGPEDNVR NLRKRQARGP GTARGCGPEV GGRRKNRQKR RMVAQASPGK
     DKVERDRSVA ASGAEKATRR RVERPRGQVS PSDRRGIQAA KEAELRLQTE RHTKEKRKVT
     EASSDDPQPE IDLVRKESLT SSESFQTVEC LQSLSKEGIV EGIKRRRIRN KKLKSLENPP
     LKVTENEATQ NIKVEFQDEL YKNTPKYSCN ILSPEVENNS ILKLHVCNCF PHSKGCNDEN
     NLPYKPDGGC MHVAENSSKL KKENLRSLAE KSDTNSIPRL LQTKESVMGV NKLLLEESDL
     CQSKTNDLLS CLQREKNKYS IEESSVGRKS RKRIKSEKAV TESETVTEMN FYEYNKSELM
     LQENKMIADG KEAETKSPLN VLRKVSHNTV SLMDHLLSLP EMVGKETSPE HHVNAVCQKT
     IEPLLKEETE NASEPLGYES MAQTEDFKSM KSSIGKSPNE YHIEKRSSQE ELRRESEELK
     LSCQRTIPMT GKRTWPYYSC ARISAWCWKK ASLPESSYFL PGSQESCRQD DVLKHQTNQT
     HLTDSKLLLQ SSLTETNIES SSKEKLDSNS NCLSSVSAIE HTLMVMKEPI IEDDKKIKSE
     ELSKSGSEVV SNTTEDTQLI SETQILTGNK KKDRGNLTKL NLIATSKDGQ EANNSTGRTI
     HRKSCVAKQT FVAPDLVKIL NTGRLTNFKI PLLKNKTEKR KEINAKSSER EAYSPLELLD
     NLSGAEVRQN RSKESVSMTT SGPQTLSIQN SVTPAQASSD SFYDKNSCSI YPRFTKQDNN
     NKPSNHISER GNIVSNKEVA SLTVENNTFS YDPGYVEKNS FFSCNEQETF QPVSSEVSVR
     KITKNFSEIK VGSPDILKAY EDDVLLIDVI QDDPDLFGVS NEGELSCTSG VSRISQEPNV
     AGEDQSADFK YMETPVKKEP SDNLRELSVL DTGSIKSEAC ASNSAASEIR HDSKDVNTSL
     GKVANKASEN ETLEDFSEQI KGSNLDKKHR FTDKVIIKEE KEKIYEVCKS KDSRNADIMV
     DECQFAAPVP KPLCLLVPPL NLSGHQEETV LNTWTNDFRF LGKHSVLKLQ NPATCEIFKR
     EKNVGVLQKS LGLMLPYKYC RFHFNTLRGC ERPLCKFVHV PEQGDEKVCM DVFKKYININ
     ELCLLQRAVN IFMEYYRKFP PGIHFDLQVL NDLLNSLLKH CLLKEVFQIV NLSIMVKIQP
     SLKILLNIFE HVATMKLRNA VPALTDIFCK LIEAGMVLDP EHFNYIVKLL YQVQASKQEI
     TAVLEMRSRL QTRLFKKNWK CDLDSALNKL EHCKEKGDWT RLGKLYLNVK MGCEKLADFE
     TFCACIAKTL TKHYEKEGPD VPFCEFAETV SKDPQNSKVD ESVLGRIGIS ALFFYHKLLQ
     WSKGRKVLDK LYELKIHFTS LKGLIGPEML ASRCQIVNVA AEIFLKSGSL NGAIWVMRES
     EWIINTPLWP CDRLDVLNRH NLLCTIAHDI LAKSLFRQAF EVLQNLPGFQ NSQETVEVSQ
     YSILFNKLLD SCIESNSLGT SSSVAEFMIS KSVPIDFSFL RRLITSLGRS CLWLKARAHY
     KSALSLGCYP QLEGNLYRKL LLIPSYLSEI EMLLAMEIFM VSNASSIQSP GTSTQILQIV
     LKRCENNQSQ RNDDYQAAVE RLIMAARISD PKLFIKHMTV NINKEQVYSL EHCSVLKWLK
     ENMKWAGKVW LFSNH