ID   TOPZ1_GORGO             Reviewed;        1694 AA.
AC   G3S077;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Protein TOPAZ1 {ECO:0000250|UniProtKB:E5FYH1};
DE   AltName: Full=Testis- and ovary-specific PAZ domain-containing protein 1 {ECO:0000250|UniProtKB:E5FYH1};
GN   Name=TOPAZ1;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important for normal spermatogenesis and male fertility.
CC       Specifically required for progression to the post-meiotic stages of
CC       spermatocyte development. Seems to be necessary for normal expression
CC       levels of a number of testis-expressed gene transcripts, although its
CC       role in this process is unclear. {ECO:0000250|UniProtKB:E5FYH1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:E5FYH1}.
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DR   AlphaFoldDB; G3S077; -.
DR   STRING; 9593.ENSGGOP00000021471; -.
DR   eggNOG; ENOG502QPIV; Eukaryota.
DR   HOGENOM; CLU_003190_0_0_1; -.
DR   InParanoid; G3S077; -.
DR   OMA; IWVMRES; -.
DR   Proteomes; UP000001519; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0007286; P:spermatid development; IBA:GO_Central.
DR   GO; GO:0048137; P:spermatocyte division; IBA:GO_Central.
DR   InterPro; IPR038952; TOPAZ1.
DR   InterPro; IPR029435; TOPAZ1_dom.
DR   PANTHER; PTHR35671; PTHR35671; 1.
DR   Pfam; PF14669; Asp_Glu_race_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Differentiation; Reference proteome; Spermatogenesis.
FT   CHAIN           1..1694
FT                   /note="Protein TOPAZ1"
FT                   /id="PRO_0000416058"
FT   REGION          1..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          600..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          891..920
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..126
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        603..629
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        891..907
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1694 AA;  191137 MW;  600C368029599629 CRC64;
     MRRPPPLGPT TASGPEGNVR NLQKRQAPGP GAAGGCGPEA GGRRENKQKR RMVARATPGR
     GEVESDKSVA ASGAGKAARR RVEGRRGQVS PSDSSDPRGL EAAKEAELPL QTERHTKEKR
     KVTEASSDDP QPGLDLVRKE SLTSSESFQT VECLQSLGKE SIIEGIKRRI RNKKLKSLEN
     PPLKITENEA TQNIKVEFQD ELYKNTPKYS CNILSPEVEN NSVLKLRDCN CFPHSKGCND
     ENNLPYKPDG GCMHVAENFS KKENLRSLAE KSDTNSIPQL LQTEENVMEV NKLLPEESDL
     YQSKTNGLLS CLQHEKNKYS IEESSVGRKP RKRMKLSEKA DETVTEMNFS NEYNKSELML
     QENQMIADGK EAETKSPLNV LRKVSHNTVS LMDHLLSVPE TVEKETSSEH HVNAVFQKTI
     EPLLKEETES TSEPLGYESM ASKEDFKSMK SFIGKSPNEY HIERRSSRED LRSASEELNL
     SCQRTIPMTG KRTWPCYSCA RISAWCWKKA SLPESSYFFP GSQESYRQVD VPKHQTNQTH
     LTDSKLLLQS SLTETNTESS SKEKLDSNSN CLSSVSAVEP TLMVIKEPII KDDKKIKSEE
     LSRSGSEVIS NTTEDTQLTS ETQSLTGNKK KARGNLMKLN LTATSKDGQE ANNSAGKTIH
     RKACIAQQTF IVPDLVKILN TGRLTNFKIP LLKNKTEKRK EVNAKSSERE AYSPLELLDN
     LSGADIRQNR SKENVSMTML GPQTLSIRNS VTPVQASSDS FYNKKSYSIS PSFTKQGNNS
     KPSNHVSEPG NIVSNKEVAS LTVENNAFSC DPGYVEKSPS FCCNEQETFR PVSSEVRGRK
     ITKNFSEVGF PDILKAYEDD ILLIDVIQDD PDLFGVSNEG ELSFTSEVPK ISQEEPNVAG
     EHQSTDSKYM ETPVKKEPSD DLRELPVLDC GWIKPDICAS NSAESEIKHD PKDVNTSLGE
     VANETSENET LGDFSEQIKG SDLDEKHRFT DKVITKEEKE NIYEVCKSKD SRNADIMVGE
     CQFAVPVPKP LCLLVPPLNL SGRQEDTILN TWMNGTICFL NEILLAFGNI ETRRFFYQKQ
     KTIKVFQKSL GLMIPYKYCK FHFNTLRGCE RPLCKFAHVP EQGDEKVCMD VFKKYININE
     LCLLQRAVNI FMEYYRKFPP GVYFDLQVLN DLLNSLLKHC LLKEVFQIVN LSIMVKMLPS
     LKILLNIFEY VATMKLRNAV PALIDIFCKL VEAGMVLDPE HFNYIVKLLY QVQASKQEIT
     AVLEMKSRLQ MRQFKKNWKC DLHSALNKLE HCKEKGDWTK LGKLYINVKM GCEKFADFQT
     FCACIAETLT KNYEDERPDI PFCEFAETVS KDPQNSKVDK GVLGRIGISA MCFYHKLLQW
     SKGRKVLEKL YELKIHFTSL KGLIGPEKLA SRCQIVNVAA EIFLKSGSLD GAIWVMRESE
     WIINTPLWPC DRLDVLNRHN LLCTIAHEIL AKSLYRQTFE VLQNLPGFQN SQETVEVSQY
     SLLFNKLLGS CIESSSLGMS SSVAEFMISK SIPIDFSFLR RLITSLGRSC LWLKARAHYK
     SALSLGCYPP LEGNLYRKLL LIPSYLSEIE MLLAIEIFMV SNASSIQSPG TSTQILQIVL
     KRCEDNQSRS SDDYQAAVER LIMAARISDP KLFVKHMTVN VNKEQVYSLE HCSALKWLKE
     NMKWAGKVWL FSNH