ID   TOPZ1_MACFA             Reviewed;        1687 AA.
AC   G7NY55; Q95JY4;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Protein TOPAZ1 {ECO:0000250|UniProtKB:E5FYH1};
DE   AltName: Full=Testis- and ovary-specific PAZ domain-containing protein 1 {ECO:0000250|UniProtKB:E5FYH1};
GN   Name=TOPAZ1; ORFNames=QtsA-12362;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-696.
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: Important for normal spermatogenesis and male fertility.
CC       Specifically required for progression to the post-meiotic stages of
CC       spermatocyte development. Seems to be necessary for normal expression
CC       levels of a number of testis-expressed gene transcripts, although its
CC       role in this process is unclear. {ECO:0000250|UniProtKB:E5FYH1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:E5FYH1}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB62988.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CM001277; EHH51375.1; -; Genomic_DNA.
DR   EMBL; AB070043; BAB62988.1; ALT_FRAME; mRNA.
DR   AlphaFoldDB; G7NY55; -.
DR   STRING; 9541.XP_005546877.1; -.
DR   eggNOG; ENOG502QPIV; Eukaryota.
DR   Proteomes; UP000009130; Chromosome 2.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR038952; TOPAZ1.
DR   InterPro; IPR029435; TOPAZ1_dom.
DR   PANTHER; PTHR35671; PTHR35671; 1.
DR   Pfam; PF14669; Asp_Glu_race_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Differentiation; Reference proteome; Spermatogenesis.
FT   CHAIN           1..1687
FT                   /note="Protein TOPAZ1"
FT                   /id="PRO_0000416059"
FT   REGION          1..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          319..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          596..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          880..916
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..337
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..620
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        880..901
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        902..916
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        105
FT                   /note="F -> L (in Ref. 2; BAB62988)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        219
FT                   /note="F -> S (in Ref. 2; BAB62988)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        285
FT                   /note="M -> I (in Ref. 2; BAB62988)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        694..696
FT                   /note="RKE -> KKK (in Ref. 2; BAB62988)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1687 AA;  190437 MW;  8FF3E8673A8E86C8 CRC64;
     MRRPPPLGPT TASGPEGNVR NLRKRQAPGP GAAGGCGPEA GGRGENRQKR RMVARATPGR
     GEVKSDKSVA ASGAGKAARR RVEGRRGQVS PSDRRGLEAA KEAEFPLQTE RHTKEKRKVT
     EASSDDPQPG FDLVRKESLT SSESFQTVEC LRSLGKEGIV EGIKRRIRNK KLKSLENPPL
     KITENEATQN IKVEFQDELY KNTLKYSCNI LSPEVENNFV FKLRDCNCFP HSKDCNDENN
     LPYEPDGGCM HVAENFSKKE NFRSLAEKSD TNNIPQLLQT EENVMGVNKL LPEESDLYQS
     KINGLLPCLQ REKNKYSIEE SSVGRKPRKR MKLSEKADET VTQMNFSNEY NKSELMLQEN
     QMIADGKEAE AKSPLNVLRK VSHNTVSLMD HLLSVPEMVE KETSSEHHVN AVFQKTIEPL
     LKEETENASE PLGYENMALK EDFKSKSCIG KSPEYHIERR SSREDLRSDS EELKLSCQRT
     IPMTGKRTWP YYSCARISAW CWKKASLPES SYFLPGSQKS CKKVDVPKHQ TNKTHLTDSK
     LLLQSSLTET NTESSSKEKL DSNLNCLFSV SAVEHTLMVI KEPIIKDDKK IKSEELSRSG
     SEVISNTTED TQLTSDTQSL TGNKKRDRGN LTKLNLTAAS KDGQEANNST GKTIHRKACV
     AKQTFVVPDL VKILNTGRLT NFKIPLLKNK TKKRKEVNAK SSEREGYSPL ELLDNLSGAD
     TRQNRSKENV SMTMLGPQTL SIQNSVTPVQ ASSDSFYNKN SCSISPSFTK HGNSSKPSNH
     FSEPGNIVSN KEVASLTVEN NAFSCDPGYV EKSPSFCCNK QETFRPVSSE VRGRKITKNF
     SEVGFPDILK AYEDDVLLID VIQDDPDLFG VSNEGELSFT SEVPRISQEP NVPGEHQSTD
     SKYVETPVKK EPSDDLRELP VLDCGPIKPD ICASNSAASE IKHDPKDANT SLGEVANETS
     ENETLGDFSE QIKGSDLDEK HRFTDKVITK EEKENIYEVR KSKDSRNADI MVGECQFAAP
     VPKPLCLLVP PLNLSGHQED TILNTWMNDF RFLGKHSVLK LQNPETCEIF KREKNVGVFQ
     KSLGLMIPYK YCKFHFNTLR GCERPLCKFA HVPEQGDEKV CMDVFKKYIN INELCLLQRA
     VNVFMEYYRK FPPGIYFDLQ VLNDLLNSLL KHCLLKEVFQ IVNLSIMVKM LPSLKILLNI
     FEHVATMKLR NAVPALIDIF CKLVEAGMVL DPEHFNYIVK LLYQVQASKQ EITAVLEMKS
     RLQMRQFKKN WKCDLDSALN KLEHCKEKGD WTKLGKLYIN VKMGCEKFAD FQTFCACIAE
     TLTKNCEDER PDTPFCEFAE TVSKDPQNSK VDKGVLGRIG ISAMYFYHKL LQWSKGRKVL
     DKLYELKIHF ASLKGLIGPE KLASRCQIVN VAAEIFLKSG SLDGALWVMR ESEWIIDTPL
     WPCDRLDVLN RHNLLCTIAH ETLAKSLYRQ TFEVLQNLPG FQNSQETVEV SQYSLLFNKL
     LGSCIESNSL GMSSSVAEFM ISKSIPIDFS FLRRLITSLG RSRLWLKARA HYKSALSLGC
     YPPLEGNLYR KLLLIPSYLS EIEMLLAIEI FMVSNASSIQ SPGTSTQILQ IVLKRCEDNQ
     SRSNDDYQAA VERLIMAARI SDPKLFVKHM TVNVNKEQVY SLEHCSALKW LKENMKWAGK
     VWLFSNH