ID   TOPZ1_RAT               Reviewed;        1646 AA.
AC   D3ZUC6; R9PXW9;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-APR-2018, sequence version 2.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Protein TOPAZ1 {ECO:0000250|UniProtKB:E5FYH1};
DE   AltName: Full=Testis- and ovary-specific PAZ domain-containing protein 1 {ECO:0000250|UniProtKB:E5FYH1};
GN   Name=Topaz1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
CC   -!- FUNCTION: Important for normal spermatogenesis and male fertility.
CC       Specifically required for progression to the post-meiotic stages of
CC       spermatocyte development. Seems to be necessary for normal expression
CC       levels of a number of testis-expressed gene transcripts, although its
CC       role in this process is unclear. {ECO:0000250|UniProtKB:E5FYH1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:E5FYH1}.
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DR   EMBL; AABR07071813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006244267.1; XM_006244205.3.
DR   AlphaFoldDB; D3ZUC6; -.
DR   STRING; 10116.ENSRNOP00000032345; -.
DR   PhosphoSitePlus; D3ZUC6; -.
DR   PaxDb; D3ZUC6; -.
DR   PRIDE; D3ZUC6; -.
DR   GeneID; 301075; -.
DR   UCSC; RGD:1563398; rat.
DR   CTD; 375337; -.
DR   RGD; 1563398; Topaz1.
DR   VEuPathDB; HostDB:ENSRNOG00000025601; -.
DR   eggNOG; ENOG502QPIV; Eukaryota.
DR   HOGENOM; CLU_003190_0_0_1; -.
DR   InParanoid; D3ZUC6; -.
DR   OMA; IWVMRES; -.
DR   OrthoDB; 347766at2759; -.
DR   PhylomeDB; D3ZUC6; -.
DR   TreeFam; TF338635; -.
DR   PRO; PR:D3ZUC6; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000025601; Expressed in kidney and 3 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; ISO:RGD.
DR   GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0098781; P:ncRNA transcription; ISO:RGD.
DR   GO; GO:1901995; P:positive regulation of meiotic cell cycle phase transition; ISO:RGD.
DR   GO; GO:0007286; P:spermatid development; ISO:RGD.
DR   GO; GO:0048137; P:spermatocyte division; ISO:RGD.
DR   InterPro; IPR038952; TOPAZ1.
DR   InterPro; IPR029435; TOPAZ1_dom.
DR   PANTHER; PTHR35671; PTHR35671; 1.
DR   Pfam; PF14669; Asp_Glu_race_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Differentiation; Reference proteome; Spermatogenesis.
FT   CHAIN           1..1646
FT                   /note="Protein TOPAZ1"
FT                   /id="PRO_0000416062"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          850..877
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        407..421
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..439
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1646 AA;  184593 MW;  46B759B161E328A2 CRC64;
     MRPPTTPPVP TTAPGRQGAT GGLRKRGLRL TPEPGEGGGC SLEARGREEE SRQKRRMVAQ
     ASGREETEAK ENGKVTEAPS DEPQPGTDLV RKTSITNSES LQTVECSEFQ SMAFLQSLAK
     EELVEGIKRR IQIKKCKSSE NPPLKITKNE ATQNIMVESQ DELFKNTPKY SCNSLSPGVE
     KNCSFESHDF SFLHSEGCNN KNGFEDEPHG VCLHAEENSL KSKKENLRNL AEKDDTKTTK
     FLKTEKNVIA SKLLLEESHL YQNKNNGLTS CLQSEKNKYS VEENNTGRKH RKKMKLSEKE
     EKGIDLTLSN VCNNSELVLQ EHQIGMEGKE TETLEHKKSF LKALRKMNHN TLPPVDHLCL
     PETVGKTSCR HSTNVVLQKT LESSLKEDTK NASETLGCRR LQPEEYFKSM TSSTVKSPSD
     SHPMGKRSPR GDLKTDTEES KVSCRRIIPM TGKRVWPLYS CARITAECWK KTSLSDLNDS
     LPGSLGNVRQ HDFLMHQTNQ THLPDSKRLQ PSLIERTIES SSKEVYDSEL SSLSSVSSVE
     PTLLDIKETI PHDKKTKLEE PSRNGTEVVS SATEDIQLSN ITQILTGNKK KKGNLSKLNL
     TVAPQESQEA NNCANKTVHR KACITKQTLV APDLVKILNT GRLTNFKIPL LKNKTGKRGE
     VSARSSEREA YSPLELLDSL SGVEAKQNRN KENICTTSGP QSLNIHSVTP GQTSSHTFYN
     KNSCTSPSFT KKGYDNKTCN HISETGNTIS NKESLSIKIE NNTFSCDLGY MEQSSFCSKK
     QEAFVPISSE ISGRKMTKSI SELKLGFPDI LKAYEDDVLL IDVIQDDPEL FGISSEGDLS
     FASEVSKISQ EPRVSEEHPS ADFKHRHLPG KKEPGDLSKE VALLDPGLLK LEICPSLSAA
     KEPQHDPKGA AISLEATEET VISENLEDLS EQARASDSDT KCVSSDKATV VEEQENTHEV
     CKSKDSRSVE AVSTECHLAL GPNTLCSSAP PLTLSSHQDV APAPWTNDFR FPGRYSVLQL
     QNPETCEIFK REKNFGVFQK PLGLMIPHRY CKLHFNTLRG CERAQCKFVH VPEQGDEKIC
     MDVFKKYIRV NEQRLLHRAA YIFLEYYRKF PPGIHFSLQV LNDLLISLLK HCLLKEVFQV
     VQLSIMAKML PALKILLKIF EYVAAMKLRN AVPALIEIFC KFIEAGMIPD PEHLNYIVKL
     LHQAQASQQE ISAVLEAKSR LQVRQLRKNW TCDLDSALSE VENCKEKGDW TKLGNLYISI
     KMGCEEFADF QRFCACVAET LTEDYKEERP GVPFCEFAET VSKDPQYSEV DKTLLGRIGI
     SAVYFYHRLL LWSKGRKVLD ILYELKIHFT SLKGLTGPEK IAPRCQIVNV AAEIFIKSGS
     LDGAIWVLRE SEWITSTPLW PCDRADVLHR HNLLCAIAHE ILGKNLYKQT FEVLRNLPGF
     QNSQEAMGVS QSSLLFNELL DACIESNSLG ISSSVADFMV AKSIPIDFSF LRRLITSLGR
     SCLWLKARAH YKSALSLGCY PPLEGNVYRK LLLVPSYLSE IEMLLAIEIF LVSNASSIQS
     PGAPTQVLQI VLKRCEESKP RSKDDYQAAV ERLIMAARIS DPKLFIKHMT VNINKEQVYS
     LEHCSAVKWL KENMKWAGKV WLFTNH