ID   BTSR_ECO57              Reviewed;         239 AA.
AC   P0DUE6; P0AFT7; P33356; P76432; P76433; Q9ALR8;
DT   10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2021, sequence version 1.
DT   03-AUG-2022, entry version 7.
DE   RecName: Full=Transcriptional regulatory protein BtsR {ECO:0000250|UniProtKB:P0AFT5};
GN   Name=btsR {ECO:0000250|UniProtKB:P0AFT5}; Synonyms=yehT;
GN   OrderedLocusNames=Z3302, ECs2936;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system BtsS/BtsR. BtsR
CC       regulates expression of btsT by binding to its promoter region.
CC       {ECO:0000250|UniProtKB:P0AFT5}.
CC   -!- PTM: Phosphorylated by BtsS. {ECO:0000250|UniProtKB:P0AFT5}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG57193.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB36359.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG57193.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB36359.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_310963.2; NC_002695.1.
DR   RefSeq; WP_000598641.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0DUE6; -.
DR   SMR; P0DUE6; -.
DR   GeneID; 66673980; -.
DR   GeneID; 916639; -.
DR   KEGG; ece:Z3302; -.
DR   KEGG; ecs:ECs_2936; -.
DR   OMA; ENKGTYA; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..239
FT                   /note="Transcriptional regulatory protein BtsR"
FT                   /id="PRO_0000081362"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          137..239
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   239 AA;  27400 MW;  5665AAE782B7FBA3 CRC64;
     MIKVLIVDDE PLARENLRVF LQEQSDIEIV GECSNAVEGI GAVHKLRPDV LFLDIQMPRI
     SGLEMVGMLD PEHRPYIVFL TAFDEYAIKA FEEHAFDYLL KPIDEARLEK TLARLRQERS
     KQDVSLLPEN QQALKFIPCT GHSRIYLLQM KDVAFVSSRM SGVYVTSHEG KEGFTELTLR
     TLESRTPLLR CHRQYLVNLA HLQEIRLEDN GQAELILRNG LTVPVSRRYL KSLKEAIGL