ID   TOR2A_BOVIN             Reviewed;         321 AA.
AC   A4FUH1;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Torsin-2A;
DE   AltName: Full=Torsin family 2 member A;
DE   Flags: Precursor;
GN   Name=TOR2A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homohexamer. Interacts with TOR1AIP1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A4FUH1-1; Sequence=Displayed;
CC       Name=2; Synonyms=Prosalusin;
CC         IsoId=P0C7W1-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC114885; AAI14886.1; -; mRNA.
DR   RefSeq; NP_001076945.1; NM_001083476.2. [A4FUH1-1]
DR   AlphaFoldDB; A4FUH1; -.
DR   SMR; A4FUH1; -.
DR   STRING; 9913.ENSBTAP00000017963; -.
DR   PaxDb; A4FUH1; -.
DR   PRIDE; A4FUH1; -.
DR   Ensembl; ENSBTAT00000017963; ENSBTAP00000017963; ENSBTAG00000013510. [A4FUH1-1]
DR   GeneID; 534311; -.
DR   KEGG; bta:534311; -.
DR   CTD; 27433; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013510; -.
DR   eggNOG; KOG2170; Eukaryota.
DR   GeneTree; ENSGT00950000182888; -.
DR   HOGENOM; CLU_053537_0_0_1; -.
DR   InParanoid; A4FUH1; -.
DR   OMA; HQFSPIV; -.
DR   OrthoDB; 611758at2759; -.
DR   TreeFam; TF314941; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000013510; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010448; Torsin.
DR   InterPro; IPR017378; Torsin_1/2.
DR   PANTHER; PTHR10760; PTHR10760; 1.
DR   Pfam; PF06309; Torsin; 1.
DR   PIRSF; PIRSF038079; Torsin_2A; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ATP-binding; Endoplasmic reticulum; Glycoprotein;
KW   Nucleotide-binding; Reference proteome; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..321
FT                   /note="Torsin-2A"
FT                   /id="PRO_0000345620"
FT   BINDING         93..100
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        149
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   321 AA;  36170 MW;  596B27A8089D444F CRC64;
     MAAATRSCRP WGSLLGLIWL VSAAAASWDL SSLRCNFGSF CECDFQPDFQ GLECDLAQHL
     AGQHLARSLV VKALKAFLQD PAPTKPLVLS LHGWTGTGKS YVSSLLAHYL FRDGLRSPHV
     HHFSPVIHFP HPSHLERYKK DLKSWVQGNL TVCSRSLFLF DEMDKLAPGL IEVLRPFLGS
     SWVVYGTNYR KAIFIFISNT GGEQINQVVL EAWRSRRERE EIGLQELGPV ISQAVLDNPH
     HGFWRSGIME EHLLDVLVPF LPLQRHHVRH CVLNELAHLG LEPRDEVVQA VLDSTIFFPE
     DEPLFSSNGC KMVASRIAFF L