ID   TOR2A_RAT               Reviewed;         321 AA.
AC   Q6AYR4;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Torsin-2A;
DE   AltName: Full=Torsin family 2 member A;
DE   Flags: Precursor;
GN   Name=Tor2a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Homohexamer. Interacts with TOR1AIP1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6AYR4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P0C7W2-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC078943; AAH78943.1; -; mRNA.
DR   RefSeq; NP_001007745.1; NM_001007744.1. [Q6AYR4-1]
DR   AlphaFoldDB; Q6AYR4; -.
DR   SMR; Q6AYR4; -.
DR   STRING; 10116.ENSRNOP00000030747; -.
DR   GlyGen; Q6AYR4; 1 site.
DR   PaxDb; Q6AYR4; -.
DR   PRIDE; Q6AYR4; -.
DR   GeneID; 362112; -.
DR   KEGG; rno:362112; -.
DR   CTD; 27433; -.
DR   RGD; 1359111; Tor2a.
DR   VEuPathDB; HostDB:ENSRNOG00000022514; -.
DR   eggNOG; KOG2170; Eukaryota.
DR   HOGENOM; CLU_053537_0_0_1; -.
DR   InParanoid; Q6AYR4; -.
DR   OMA; HQFSPIV; -.
DR   OrthoDB; 611758at2759; -.
DR   TreeFam; TF314941; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000022514; Expressed in pancreas and 20 other tissues.
DR   ExpressionAtlas; Q6AYR4; baseline and differential.
DR   Genevisible; Q6AYR4; RN.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; ISO:RGD.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IEA:InterPro.
DR   GO; GO:1904427; P:positive regulation of calcium ion transmembrane transport; ISO:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010448; Torsin.
DR   InterPro; IPR017378; Torsin_1/2.
DR   PANTHER; PTHR10760; PTHR10760; 1.
DR   Pfam; PF06309; Torsin; 1.
DR   PIRSF; PIRSF038079; Torsin_2A; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ATP-binding; Endoplasmic reticulum; Glycoprotein;
KW   Nucleotide-binding; Reference proteome; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..321
FT                   /note="Torsin-2A"
FT                   /id="PRO_0000228831"
FT   BINDING         93..100
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        149
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   321 AA;  35871 MW;  9598BCEF271CE3EB CRC64;
     MAVARHGCPP WGSILGLLVL ALAAAAAWDV SFLRCSLGSF CECDFWPDLP GLECDLARHL
     AGQHLAKALV VKSLKAFVQD PAPSKPLVLS LHGWTGTGKS YVSSLLAQYL FRGGLRSPHV
     HHFSPIIHFP HPSHTEQYKN ELKSWVQGNL TACGRSLFLF DEMDKLPPGL MEVLKPFLGP
     SWVVYGTNYR KAIFIFISNT GGEQINQVAL EAWRSRRDRE EISLQEVEPA VSQAVLDNPH
     HGFWRSGIME EQLLDAVVPF LPLQRHHVRH CVLNELAQLG LEPREEVVQA VLDSTTYFPE
     EEQLFSSNGC KTVASRITFF L