ID   TOR2X_MOUSE             Reviewed;         231 AA.
AC   P0C7W3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Prosalusin;
DE   AltName: Full=Torsin family 2 member A;
DE   AltName: Full=Torsin-2A;
DE   Contains:
DE     RecName: Full=Salusin-beta;
DE   Flags: Precursor;
GN   Name=Tor2a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   REGION.
RX   PubMed=16697365; DOI=10.1016/j.ejphar.2006.03.064;
RA   Wang Z., Takahashi T., Saito Y., Nagasaki H., Ly N.K., Nothacker H.-P.,
RA   Reinscheid R.K., Yang J., Chang J.K., Shichiri M., Civelli O.;
RT   "Salusin beta is a surrogate ligand of the mas-like G protein-coupled
RT   receptor MrgA1.";
RL   Eur. J. Pharmacol. 539:145-150(2006).
CC   -!- FUNCTION: Salusin may be a endocrine and/or paracrine factor able to
CC       increase intracellular calcium concentrations and induce cell
CC       mitogenesis. Salusin may also be a potent hypotensive peptide (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=3;
CC         IsoId=P0C7W3-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=Q8R1J9-1; Sequence=External;
CC       Name=2;
CC         IsoId=Q8R1J9-2; Sequence=External;
CC   -!- MISCELLANEOUS: [Isoform 3]: Salusin-beta peptide is derived from
CC       isoform 3.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL772271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0C7W3; -.
DR   SMR; P0C7W3; -.
DR   PhosphoSitePlus; P0C7W3; -.
DR   PeptideAtlas; P0C7W3; -.
DR   PRIDE; P0C7W3; -.
DR   ProteomicsDB; 260652; -. [P0C7W3-1]
DR   MGI; MGI:1353596; Tor2a.
DR   ChiTaRS; Tor2a; mouse.
DR   Proteomes; UP000000589; Unplaced.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IDA:MGI.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010448; Torsin.
DR   PANTHER; PTHR10760; PTHR10760; 1.
DR   Pfam; PF06309; Torsin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; ATP-binding; Cleavage on pair of basic residues;
KW   Glycoprotein; Hormone; Nucleotide-binding; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..231
FT                   /note="Prosalusin"
FT                   /id="PRO_0000345614"
FT   PROPEP          28..189
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000345615"
FT   PEPTIDE         192..231
FT                   /note="Salusin-beta"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000345616"
FT   REGION          192..211
FT                   /note="Partial activation of MRGPRA1"
FT   BINDING         93..100
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        149
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   231 AA;  25377 MW;  56DC8F6C09F5EFC5 CRC64;
     MAVARHGYRP WGSILGLLGL ALAAAAAWDV ASLRCTFGSF CECDFWPDLP GLECDLAQHL
     AGQHLAKALV VKSLKAFVQD PAPSKPLVLS LHGWTGTGKS YVSSLLAQHL FRDGLRSPHV
     HHFSPIIHFP HPSRTEQYKK ELKSWVQGNL TACGRSLFLF DEMDKLPPGL MEVLQPFLGP
     SWVVYGTNYR KAIFIFIRWL LAVWHHGGAP AGRCGALPPA PAASRAPLRT Q