ID   TOR4A_DANRE             Reviewed;         409 AA.
AC   Q568B8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Torsin-4A;
DE   AltName: Full=Torsin family 4 member A;
GN   Name=tor4a; ORFNames=zgc:110567;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC092931; AAH92931.1; -; mRNA.
DR   RefSeq; NP_001315625.1; NM_001328696.1.
DR   AlphaFoldDB; Q568B8; -.
DR   SMR; Q568B8; -.
DR   STRING; 7955.ENSDARP00000007229; -.
DR   PaxDb; Q568B8; -.
DR   PRIDE; Q568B8; -.
DR   DNASU; 550133; -.
DR   Ensembl; ENSDART00000055140; ENSDARP00000055139; ENSDARG00000010145.
DR   Ensembl; ENSDART00000185174; ENSDARP00000154509; ENSDARG00000037843.
DR   GeneID; 101886311; -.
DR   KEGG; dre:101886311; -.
DR   ZFIN; ZDB-GENE-050417-9; tor4aa.
DR   eggNOG; KOG2170; Eukaryota.
DR   GeneTree; ENSGT00950000182888; -.
DR   HOGENOM; CLU_053537_1_0_1; -.
DR   InParanoid; Q568B8; -.
DR   PhylomeDB; Q568B8; -.
DR   TreeFam; TF314941; -.
DR   Reactome; R-DRE-114608; Platelet degranulation.
DR   PRO; PR:Q568B8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000010145; Expressed in granulocyte and 18 other tissues.
DR   ExpressionAtlas; Q568B8; baseline.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010448; Torsin.
DR   InterPro; IPR030551; Torsin-4A.
DR   PANTHER; PTHR10760; PTHR10760; 1.
DR   PANTHER; PTHR10760:SF1; PTHR10760:SF1; 1.
DR   Pfam; PF06309; Torsin; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..409
FT                   /note="Torsin-4A"
FT                   /id="PRO_0000287491"
FT   TRANSMEM        120..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          75..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         192..199
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   409 AA;  47005 MW;  9EFE1F3EF52E57D4 CRC64;
     MGEQDPSDRL RGDQLKEPNQ NGKGSFSQFS SSVRAMVRIR MKYQAIKKRR MEIASATPQI
     FTSPRSTSPK VFTFDNLHEP VNSNPASPRK RKKKRKGRVL YPTSSLRAVP TKESSRAKNC
     LYLLCIIVFL QVYNAIENLD DHVLKYDLEG LEKTLKREVF GQQEVAEGLL GHLQDYLSTY
     VHNKPLVLSF HGPTGVGKSH VGRLLAQHFR SVVGEELVMQ YFVLHHCPTD DDIPVCTKSL
     ESHISEMVSQ GEEEEKIPVF IFDEVEHMPR QLMDTLRELI QPQNSNKYLN AIYILISNLG
     HEDITKFVLH NSSIAISGRL SLTQELTPWL RNYLQEHHGL FLDAEYLPFM LLEKSHVMDC
     FIDEMSREGF YPDRSHVERL AEELSYYIVG EREFSHTGCR QVVAKVNLL