TOR4A_MOUSE
ID TOR4A_MOUSE Reviewed; 426 AA.
AC Q8BH02; Q921D7;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Torsin-4A;
DE AltName: Full=Torsin family 4 member A;
GN Name=Tor4a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Brain cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH13092.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK043559; BAC31581.1; -; mRNA.
DR EMBL; AK082899; BAC38677.1; -; mRNA.
DR EMBL; AK154508; BAE32638.1; -; mRNA.
DR EMBL; AK155540; BAE33317.1; -; mRNA.
DR EMBL; AK171551; BAE42522.1; -; mRNA.
DR EMBL; AL732309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC013092; AAH13092.1; ALT_FRAME; mRNA.
DR CCDS; CCDS15750.1; -.
DR RefSeq; NP_666227.2; NM_146115.4.
DR AlphaFoldDB; Q8BH02; -.
DR SMR; Q8BH02; -.
DR STRING; 10090.ENSMUSP00000080548; -.
DR iPTMnet; Q8BH02; -.
DR PhosphoSitePlus; Q8BH02; -.
DR EPD; Q8BH02; -.
DR jPOST; Q8BH02; -.
DR MaxQB; Q8BH02; -.
DR PaxDb; Q8BH02; -.
DR PRIDE; Q8BH02; -.
DR ProteomicsDB; 259499; -.
DR Antibodypedia; 48995; 20 antibodies from 11 providers.
DR Ensembl; ENSMUST00000081869; ENSMUSP00000080548; ENSMUSG00000059555.
DR GeneID; 227612; -.
DR KEGG; mmu:227612; -.
DR UCSC; uc008iql.2; mouse.
DR CTD; 54863; -.
DR MGI; MGI:2442720; Tor4a.
DR VEuPathDB; HostDB:ENSMUSG00000059555; -.
DR eggNOG; KOG2170; Eukaryota.
DR GeneTree; ENSGT00950000182888; -.
DR HOGENOM; CLU_053537_1_0_1; -.
DR InParanoid; Q8BH02; -.
DR OMA; HVTECFL; -.
DR OrthoDB; 757464at2759; -.
DR PhylomeDB; Q8BH02; -.
DR TreeFam; TF314941; -.
DR Reactome; R-MMU-114608; Platelet degranulation.
DR BioGRID-ORCS; 227612; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Tor4a; mouse.
DR PRO; PR:Q8BH02; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BH02; protein.
DR Bgee; ENSMUSG00000059555; Expressed in peripheral lymph node and 176 other tissues.
DR ExpressionAtlas; Q8BH02; baseline and differential.
DR Genevisible; Q8BH02; MM.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010448; Torsin.
DR InterPro; IPR030551; Torsin-4A.
DR PANTHER; PTHR10760; PTHR10760; 1.
DR PANTHER; PTHR10760:SF1; PTHR10760:SF1; 1.
DR Pfam; PF06309; Torsin; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..426
FT /note="Torsin-4A"
FT /id="PRO_0000287490"
FT TRANSMEM 117..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 41..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 189..196
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT MOD_RES 58
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NXH8"
FT MOD_RES 76
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NXH8"
FT MOD_RES 84
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NXH8"
FT MOD_RES 101
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NXH8"
SQ SEQUENCE 426 AA; 47586 MW; 5D7DF54EBEE87CD5 CRC64;
MDRSHPSLEP QAKGPCVIAP VRAVLRLRRR VCVLRKRRLL QPGTEPDSGT GTLGPTGSLG
TLRADLDQPK FFTFDSLTEL TSRTPRKRRR RSRVVLYPET SRKCRPRTER QSRAQRCLLL
LVAIVGFQVL NAIENLDDNA QRYDLDGLEK ALQRSVFGQP AAVGRIMALL RDYLATHVHS
HPLLLALHGP SGVGKSHVGR LLARHFRAVL EDGALVLQYH ARYHCPEPRP VQDCRKELAQ
RVADVVAQAE AEEKTPLLVL DEAELLPPAL LDELHDLLQP QRSHHFHNAI YVLLSGAGGI
EITHFVLQNA SRMLPPLRHS AGSTQTEESP AQELLTSLRE LLAREHPLWH TAAIVPFLLL
DKPDVVNCFR EEMAGEGFFP EQALAEHLAE QLSYYHVAGH EFAITGCKQV VAKVNLLQHK
PAHAGH
