ID   TOR4A_XENTR             Reviewed;         420 AA.
AC   Q5BKJ7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Torsin-4A;
DE   AltName: Full=Torsin family 4 member A;
GN   Name=tor4a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC091049; AAH91049.1; -; mRNA.
DR   RefSeq; NP_001025600.1; NM_001030429.1.
DR   RefSeq; XP_012809909.1; XM_012954455.2.
DR   RefSeq; XP_012809910.1; XM_012954456.2.
DR   RefSeq; XP_012809911.1; XM_012954457.2.
DR   AlphaFoldDB; Q5BKJ7; -.
DR   SMR; Q5BKJ7; -.
DR   STRING; 8364.ENSXETP00000050639; -.
DR   PaxDb; Q5BKJ7; -.
DR   DNASU; 594988; -.
DR   Ensembl; ENSXETT00000050639; ENSXETP00000050639; ENSXETG00000023451.
DR   GeneID; 594988; -.
DR   KEGG; xtr:594988; -.
DR   CTD; 54863; -.
DR   Xenbase; XB-GENE-975360; tor4a.
DR   eggNOG; KOG2170; Eukaryota.
DR   HOGENOM; CLU_053537_1_0_1; -.
DR   InParanoid; Q5BKJ7; -.
DR   OMA; HVTECFL; -.
DR   OrthoDB; 757464at2759; -.
DR   TreeFam; TF314941; -.
DR   Reactome; R-XTR-114608; Platelet degranulation.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023451; Expressed in neurula embryo and 11 other tissues.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010448; Torsin.
DR   InterPro; IPR030551; Torsin-4A.
DR   PANTHER; PTHR10760; PTHR10760; 1.
DR   PANTHER; PTHR10760:SF1; PTHR10760:SF1; 1.
DR   Pfam; PF06309; Torsin; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..420
FT                   /note="Torsin-4A"
FT                   /id="PRO_0000287494"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         202..209
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   420 AA;  48393 MW;  73852D3AD212EE21 CRC64;
     MEDSESSTQA PAAHHGISLA SSPVRALIRM RRKIRTLKKS RLQLDLTTGR PLDSAKASLR
     RQISTDRASL FKTTTYEKQQ YFNFDTPTLE KLALNNQIRK KNRKKSRHVL YPGNVRKCLP
     VEQKSKAKRC LLLFIAIVCF QIFNAIENLD DNLQKYDLDG LEKTLQREVF GQRRAIDKLM
     DHLKDYLATH YHNKPLVLSF NGPSGVGKSH TGRLLAKHFR SVMDNDFVLQ YYTMHNCPDE
     NDVAKCQAEV SGMISEMISR AEIEEKIPVF IFDELEVMPV ALLDVLHGYF QLNQSNEYLN
     AVYILISNIG GNEITKFVLQ NSSKDFVNVP QELRHLVLTS LRKQHFLWDV AEIVPFTLLE
     KRHILDCFLD ELLREGLYPD HSNIESLAGQ LRYYTKENKE YSITGCKQVV AKVNLLQPYT