ID   TORA_DICDI              Reviewed;         808 AA.
AC   Q8T133; Q551S5; Q9GSH4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Protein tortoise;
GN   Name=torA; ORFNames=DDB_G0276353;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=11157987; DOI=10.1083/jcb.152.3.621;
RA   van Es S., Wessels D., Soll D.R., Borleis J., Devreotes P.N.;
RT   "Tortoise, a novel mitochondrial protein, is required for directional
RT   responses of Dictyostelium in chemotactic gradients.";
RL   J. Cell Biol. 152:621-632(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for efficient chemotaxis.
CC       {ECO:0000269|PubMed:11157987}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11157987}.
CC   -!- DISRUPTION PHENOTYPE: Mutants have no defect in cAMP signaling or
CC       motility, but are unable to respond to a spatial gradient with directed
CC       movement. {ECO:0000269|PubMed:11157987}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF303221; AAG30251.1; -; mRNA.
DR   EMBL; AAFI02000014; EAL69257.1; -; Genomic_DNA.
DR   RefSeq; XP_643175.1; XM_638083.1.
DR   AlphaFoldDB; Q8T133; -.
DR   SMR; Q8T133; -.
DR   STRING; 44689.DDB0185067; -.
DR   PaxDb; Q8T133; -.
DR   PRIDE; Q8T133; -.
DR   EnsemblProtists; EAL69257; EAL69257; DDB_G0276353.
DR   GeneID; 8620447; -.
DR   KEGG; ddi:DDB_G0276353; -.
DR   dictyBase; DDB_G0276353; torA.
DR   eggNOG; ENOG502RGRR; Eukaryota.
DR   HOGENOM; CLU_348985_0_0_1; -.
DR   InParanoid; Q8T133; -.
DR   OMA; YFIGIQD; -.
DR   PRO; PR:Q8T133; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005739; C:mitochondrion; IDA:dictyBase.
DR   GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR   GO; GO:0016477; P:cell migration; IMP:dictyBase.
DR   GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Coiled coil; Mitochondrion; Reference proteome.
FT   CHAIN           1..808
FT                   /note="Protein tortoise"
FT                   /id="PRO_0000327929"
FT   REGION          152..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          43..78
FT                   /evidence="ECO:0000255"
FT   COILED          694..733
FT                   /evidence="ECO:0000255"
FT   CONFLICT        52
FT                   /note="N -> D (in Ref. 1; AAG30251)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   808 AA;  94227 MW;  3091C5367E0B74F6 CRC64;
     MNKTIIINNV SKYIKFKNYY SSSSTILKKK TSEIYKIKGL DIKDRKELYS LNNDSIKKKL
     NQLKDETNQL LKERGEELMK DLSKTLNLTS DNLKYNITKS PFTLRAYLLA ANQGISFYHH
     ELRKQINPTD DYERQKRKDL VYKLQSQEID SLTSGGANKK KSPFLEDNNN KKSMSIEREM
     EIIREQQQEQ QHFDQQMSNS TKWEMSQLEI QPRIDTFRQD ELFVSFNPYE SMSTNSQSYQ
     LVSRLSKFVW NKELTNWEMF SSSKLNQLIP QLQLHILDKI NLNNDNDNDN SIIINQFLES
     IKFISNEINS TDLNIFKTLN SSNNNNNSSE NIIEVENGGD FKKIINNSIV DSLIYMKGHH
     FRITSDPFIL FFQQLKENQD YFTSNEDYKQ FLEKLLDTLL FETIEFDPTS TTTINGNRQF
     EYKLKLDLLQ REAFRQFKVY QVFNTSPDAK RHEESDLRKL AHLCKTLQKR STSDFIQESK
     KYLSPQILSN GLLNSNKLLV ATSSSNELNQ SKTSISISQL TDGLHSCIPA TMSLLEFSIK
     NSSKDNILFD TFDGKLKNIN SLDDLITKFA NSKYIYLRES LSQRFSMFIQ SSNNTTDNNT
     TTDTNDNDII IGLNNPIYKL LIDLEDKVLE LSQNNFEENP IENWIGCLSI ELGDEDDNIE
     YKDTDQFNVI ASQNFNLVRI NNQMLAQLHK TFSEDLDFQI EELELMIKNK KILEREIKAH
     NEKISKIIKD SRDSTTPTFY FIGIQDDQVY TLEIPNEWEP VWNLLKSYPN GLLLKDFIDK
     QTFVTKEAFL STLTDLNKYG VVGLFPKN