ID   BTSR_SALTI              Reviewed;         239 AA.
AC   Q8Z5C1;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=Transcriptional regulatory protein BtsR {ECO:0000250|UniProtKB:P0AFT5};
GN   Name=btsR {ECO:0000250|UniProtKB:P0AFT5}; Synonyms=yehT;
GN   OrderedLocusNames=STY2388, t0697;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Member of the two-component regulatory system BtsS/BtsR. BtsR
CC       regulates expression of btsT by binding to its promoter region.
CC       {ECO:0000250|UniProtKB:P0AFT5}.
CC   -!- PTM: Phosphorylated by BtsS. {ECO:0000250|UniProtKB:P0AFT5}.
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DR   EMBL; AL513382; CAD02538.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68394.1; -; Genomic_DNA.
DR   RefSeq; NP_456718.1; NC_003198.1.
DR   RefSeq; WP_000598632.1; NZ_WSUR01000002.1.
DR   AlphaFoldDB; Q8Z5C1; -.
DR   SMR; Q8Z5C1; -.
DR   STRING; 220341.16503399; -.
DR   EnsemblBacteria; AAO68394; AAO68394; t0697.
DR   KEGG; stt:t0697; -.
DR   KEGG; sty:STY2388; -.
DR   PATRIC; fig|220341.7.peg.2412; -.
DR   eggNOG; COG3279; Bacteria.
DR   HOGENOM; CLU_000445_14_1_6; -.
DR   OMA; IQAFEEH; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..239
FT                   /note="Transcriptional regulatory protein BtsR"
FT                   /id="PRO_0000081364"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          137..239
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   CONFLICT        131
FT                   /note="Q -> S (in Ref. 2; AAO68394)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   239 AA;  27392 MW;  F35AA90C75F5225C CRC64;
     MIKVLIVDDE PLARENLRIL LQGQDDIEIV GECANAVEAI GAVHKLRPDV LFLDIQMPRI
     SGLEIVGMLD PEHRPYIVFL TAFDEYAIKA FEEHAFDYLL KPIEEKRLEK TLHRLRQERS
     KQDVSLLPEN QQALKFIPCT GHSRIYLLQM DDVAFVSSRM SGVYVTSSEG KEGFTELTLR
     TLESRTPLLR CHRQFLVNMA HLQEIRLEDN GQAELILRNG LTVPVSRRYL KSLKEAIGL