ID   BTSR_SHIFL              Reviewed;         239 AA.
AC   P59640;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-APR-2003, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Transcriptional regulatory protein BtsR {ECO:0000250|UniProtKB:P0AFT5};
GN   Name=btsR {ECO:0000250|UniProtKB:P0AFT5}; Synonyms=yehT;
GN   OrderedLocusNames=SF2197, S2324;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Member of the two-component regulatory system BtsS/BtsR. BtsR
CC       regulates expression of btsT by binding to its promoter region.
CC       {ECO:0000250|UniProtKB:P0AFT5}.
CC   -!- PTM: Phosphorylated by BtsS. {ECO:0000250|UniProtKB:P0AFT5}.
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DR   EMBL; AE005674; AAN43723.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17541.1; -; Genomic_DNA.
DR   RefSeq; NP_708016.2; NC_004337.2.
DR   RefSeq; WP_005048999.1; NZ_WPGW01000249.1.
DR   AlphaFoldDB; P59640; -.
DR   SMR; P59640; -.
DR   STRING; 198214.SF2197; -.
DR   EnsemblBacteria; AAN43723; AAN43723; SF2197.
DR   EnsemblBacteria; AAP17541; AAP17541; S2324.
DR   GeneID; 1027504; -.
DR   GeneID; 58391933; -.
DR   KEGG; sfl:SF2197; -.
DR   KEGG; sfx:S2324; -.
DR   PATRIC; fig|198214.7.peg.2625; -.
DR   HOGENOM; CLU_000445_14_1_6; -.
DR   OMA; ENKGTYA; -.
DR   OrthoDB; 1958442at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR007492; LytTR_DNA-bd_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF04397; LytTR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00850; LytTR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50930; HTH_LYTTR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..239
FT                   /note="Transcriptional regulatory protein BtsR"
FT                   /id="PRO_0000081369"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          137..239
FT                   /note="HTH LytTR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   239 AA;  27414 MW;  0D4718CCA7DB4386 CRC64;
     MIKVLIVDDE PLARENLRIF LQEQSDIEIV GECSNAVEGI GAVHKLRPDV LFLDIQMPRI
     SGLEMVGMLD PEHRPYIVFL TAFDEYAIKA FEEHAFDYLL KPIDEARLEK TLARLRQERS
     KQDVSLLPEN QQALKFIPCT GHSRIYLLQM KDVAFVSSRM SGVYVTSHEG KEGFTELTLR
     TLESRTPLLR CHRQYLVNLA HLQEIRLEDN GQAELILRNG LTVPVSRRYL KSLKEAIGL