ID   TORR_ECO57              Reviewed;         230 AA.
AC   P58357;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=TorCAD operon transcriptional regulatory protein TorR;
GN   Name=torR; OrderedLocusNames=Z1412, ECs1150;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system TorS/TorR
CC       involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO).
CC       Phosphorylated TorR activates the transcription of the torCAD operon by
CC       binding to four decameric boxes located in the torCAD promoter. Box1, 2
CC       and 4 contain the DNA sequence 5'-CTGTTCATAT-3' and box3 contains the
CC       DNA sequence 5'-CCGTTCATCC-3'. Phosphorylated as well as
CC       unphosphorylated TorR negatively regulates its own expression by
CC       binding to box1 and 2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated and dephosphorylated by TorS. {ECO:0000250}.
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DR   EMBL; AE005174; AAG55542.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34573.1; -; Genomic_DNA.
DR   PIR; B85635; B85635.
DR   PIR; F90772; F90772.
DR   RefSeq; NP_309177.1; NC_002695.1.
DR   RefSeq; WP_001120119.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P58357; -.
DR   SMR; P58357; -.
DR   STRING; 155864.EDL933_1333; -.
DR   EnsemblBacteria; AAG55542; AAG55542; Z1412.
DR   EnsemblBacteria; BAB34573; BAB34573; ECs_1150.
DR   GeneID; 914140; -.
DR   KEGG; ece:Z1412; -.
DR   KEGG; ecs:ECs_1150; -.
DR   PATRIC; fig|386585.9.peg.1266; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_4_6; -.
DR   OMA; EMGSDDY; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..230
FT                   /note="TorCAD operon transcriptional regulatory protein
FT                   TorR"
FT                   /id="PRO_0000081256"
FT   DOMAIN          4..117
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        132..227
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         53
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   230 AA;  26269 MW;  C5543487C4F7BBA1 CRC64;
     MPHHIVIVED EPVTQARLQS YFTQEGYTVS VTASGAGLRE IMQNQPVDLI LLDINLPDEN
     GLMLTRALRE RSTVGIILVT GRSDRIDRIV GLEMGADDYV TKPLELRELV VRVKNLLWRI
     DLARQAQPYT QDNCYRFAGY CLNVSRHTLE RDGEPIKLTR AEYEMLVAFV TNPGEILSRE
     RLLRMLSARR VENPDLRTVD VLIRRLRHKL SADLLVTQHG EGYFLAADVC