ID   TOR_SCHJA               Reviewed;         414 AA.
AC   Q5DC12;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Tetraspanning orphan receptor {ECO:0000250|UniProtKB:C4QM85};
DE   AltName: Full=Complement C2 receptor inhibitor tetraspanning {ECO:0000250|UniProtKB:C4QM85};
DE   AltName: Full=Complement C2 receptor inhibitor trispanning {ECO:0000250|UniProtKB:C4QM85};
DE   AltName: Full=Trispanning orphan receptor {ECO:0000303|PubMed:16617374};
GN   Name=TOR {ECO:0000250|UniProtKB:C4QM85};
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAW26644.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=16617374; DOI=10.1371/journal.ppat.0020029;
RA   Liu F., Lu J., Hu W., Wang S.-Y., Cui S.-J., Chi M., Yan Q., Wang X.-R.,
RA   Song H.-D., Xu X.-N., Wang J.-J., Zhang X.-L., Zhang X., Wang Z.-Q.,
RA   Xue C.-L., Brindley P.J., McManus D.P., Yang P.-Y., Feng Z., Chen Z.,
RA   Han Z.-G.;
RT   "New perspectives on host-parasite interplay by comparative transcriptomic
RT   and proteomic analyses of Schistosoma japonicum.";
RL   PLoS Pathog. 2:268-281(2006).
CC   -!- FUNCTION: Cell surface receptor that binds to human complement C2a
CC       protein. This results in inhibition of the classical and lectin
CC       pathways of complement activation, probably due to interference with
CC       binding of C2a to C4b and interference with cleavage by C1 or MASP2
CC       such that C3 convertase cannot be formed. This infers resistance to
CC       complement-mediated cell lysis, allowing parasite survival and
CC       infection (By similarity). {ECO:0000250|UniProtKB:Q5J7P3,
CC       ECO:0000250|UniProtKB:Q9BLM6}.
CC   -!- SUBUNIT: Interacts (via N-terminal extracellular domain) with human
CC       C2a. {ECO:0000250|UniProtKB:Q9BLM6}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BLM6};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BLM6}.
CC   -!- DEVELOPMENTAL STAGE: Highly expressed in parasitic larvae (cercariae).
CC       {ECO:0000269|PubMed:16617374}.
CC   -!- PTM: Phosphorylated on tyrosine residues.
CC       {ECO:0000250|UniProtKB:Q9BLM6}.
CC   -!- MISCELLANEOUS: Potential vaccine candidate molecule.
CC       {ECO:0000250|UniProtKB:Q9BLM6}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY814912; AAW26644.1; -; mRNA.
DR   AlphaFoldDB; Q5DC12; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Phosphoprotein; Receptor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..414
FT                   /note="Tetraspanning orphan receptor"
FT                   /id="PRO_0000412759"
FT   TOPO_DOM        1..28
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..166
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..194
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..241
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..414
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          306..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..324
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  46480 MW;  35815A6DB79B105B CRC64;
     MPRASALLTS DPRHQFTCCL CLHVRTGTII FGITQIIIQL IFISFLFLMT FNPRLFPEDN
     HGSLDSSQAN ARYYVLSALF RLVPAVSDIH ESLTFPSFPE VRNVNDNKLL FGHNSESEVN
     FNFDISSGYK DSVPIDMSHS PSRLMSETHK RERGSREIKI RQFSPYIAVC VTTFSLAFCC
     FMVHGAITRQ PTHLLPFFFI QVFDLIICLI HILGFMSSTS DIRLMIHTKT GPIYIKSTGL
     AFIILSISCM MLAFKAYCLG MVWDCYKYLM LNRRNNVLNE WYSDQWGHFS TFWSLLRAGR
     NRGNNLTGNL DSANESNTRA HPDPVTYDPS NDLPKYDDIL KIPANAYAPP PYYCSNINGN
     GNLTQANAVT ANTTSTNVST FTTTTTTANT TTNVTSANKN DAEVTSTPSN VHPC