TOS1_YEAST
ID TOS1_YEAST Reviewed; 455 AA.
AC P38288; D6VQF7;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Protein TOS1;
DE AltName: Full=Target of SBF 1;
DE Flags: Precursor;
GN Name=TOS1; OrderedLocusNames=YBR162C; ORFNames=YBR1213;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7597849; DOI=10.1002/yea.320110508;
RA Baur S., Becker J., Li Z., Niegemann E., Wehner E., Wolter R., Brendel M.;
RT "Sequence analysis of a 5.6 kb fragment of chromosome II from Saccharomyces
RT cerevisiae reveals two new open reading frames next to CDC28.";
RL Yeast 11:455-458(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 12300 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the PGA52 family. {ECO:0000305}.
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DR EMBL; X80224; CAA56511.1; -; Genomic_DNA.
DR EMBL; Z36031; CAA85122.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07277.1; -; Genomic_DNA.
DR PIR; S46033; S46033.
DR RefSeq; NP_009720.1; NM_001178510.1.
DR AlphaFoldDB; P38288; -.
DR BioGRID; 32861; 77.
DR DIP; DIP-4932N; -.
DR IntAct; P38288; 20.
DR STRING; 4932.YBR162C; -.
DR iPTMnet; P38288; -.
DR MaxQB; P38288; -.
DR PaxDb; P38288; -.
DR PRIDE; P38288; -.
DR EnsemblFungi; YBR162C_mRNA; YBR162C; YBR162C.
DR GeneID; 852459; -.
DR KEGG; sce:YBR162C; -.
DR SGD; S000000366; TOS1.
DR VEuPathDB; FungiDB:YBR162C; -.
DR eggNOG; ENOG502QSI7; Eukaryota.
DR GeneTree; ENSGT00940000176743; -.
DR HOGENOM; CLU_030276_0_0_1; -.
DR InParanoid; P38288; -.
DR OMA; FEFEMPS; -.
DR BioCyc; YEAST:G3O-29112-MON; -.
DR PRO; PR:P38288; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38288; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0009277; C:fungal-type cell wall; IDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR InterPro; IPR018805; YJL171C/Tos1_C.
DR InterPro; IPR018807; YJL171C/Tos1_N.
DR Pfam; PF10287; DUF2401; 1.
DR Pfam; PF10290; DUF2403; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..455
FT /note="Protein TOS1"
FT /id="PRO_0000022563"
FT REGION 158..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 236
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 417
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 455 AA; 47994 MW; 193A1D0AA831768A CRC64;
MLQKLSMTAL VGLFSSVVSL VNADCTYSGG NYYCAQTDAI IYSNVGLSAT YQDVTNMDES
SCACTQADFT ASGSLAPFNE ELSVHFRGPI ELLQFGVYYP NGESNALKKR SEKQSIESCK
EGEAVVSRHK HQHKRDVAVE YVQVTSTVYV DSNGQTVTAD STNTVVGPAV PSSYTKDSTV
LSSSAQAVET SESQSSISSS KTTSSAAAAS SSSSSSSNTN GDWSRGSYFV PGSTSNCTFM
NNQGGTAGSG VWSSCFGNSI SFAASDGVSG AASAQALGDV TIKSGNEFMI FSGEECSGNN
GDCGYYREGI PAYHGFGGAD KIFVFEFSMP SDTSGSAYNQ DMPAIWLLNA KIPRTLQYGD
ASCSCWKTGC GEMDLFEILT AGSDKLISHI HDGQDGGTQD YFERPTDGTL KAAVIFNSSD
KTIHIIEVDE SFDATLSDDV VDQWLSKSGS SAALP
