ID   TOS6_VANPO              Reviewed;         106 AA.
AC   A7TLD4;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Protein TOS6;
DE   Flags: Precursor;
GN   Name=TOS6; ORFNames=Kpol_1020p23;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000305}. Membrane
CC       {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
CC   -!- PTM: The GPI-anchor is attached to the protein in the endoplasmic
CC       reticulum and serves to target the protein to the cell surface. There,
CC       the glucosamine-inositol phospholipid moiety is cleaved off and the
CC       GPI-modified mannoprotein is covalently attached via its lipidless GPI
CC       glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TOS6 family. {ECO:0000305}.
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DR   EMBL; DS480414; EDO16915.1; -; Genomic_DNA.
DR   RefSeq; XP_001644773.1; XM_001644723.1.
DR   AlphaFoldDB; A7TLD4; -.
DR   STRING; 436907.A7TLD4; -.
DR   EnsemblFungi; EDO16915; EDO16915; Kpol_1020p23.
DR   GeneID; 5545101; -.
DR   KEGG; vpo:Kpol_1020p23; -.
DR   eggNOG; ENOG502SCUF; Eukaryota.
DR   HOGENOM; CLU_2225191_0_0_1; -.
DR   InParanoid; A7TLD4; -.
DR   OMA; CSGGCTP; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell wall; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..84
FT                   /note="Protein TOS6"
FT                   /id="PRO_0000402234"
FT   PROPEP          85..106
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000402235"
FT   LIPID           84
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        72
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   106 AA;  10615 MW;  06D6F31C31ABD4D1 CRC64;
     MKFSTVAATI ASTFAVASAA SESVTYVDIT VTPEVTTSMV STVKVTSTPY TTTTLSFAVQ
     SNSVSHNETT SNSTQTTTVS LFEGAGNTAQ VGAGALVAAV AAALLL