ID   TOS6_YEAS8              Reviewed;         102 AA.
AC   C8ZGM3;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Protein TOS6;
DE   Flags: Precursor;
GN   Name=TOS6; ORFNames=EC1118_1N9_0353g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000305}. Membrane
CC       {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
CC   -!- PTM: The GPI-anchor is attached to the protein in the endoplasmic
CC       reticulum and serves to target the protein to the cell surface. There,
CC       the glucosamine-inositol phospholipid moiety is cleaved off and the
CC       GPI-modified mannoprotein is covalently attached via its lipidless GPI
CC       glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TOS6 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FN393086; CAY82313.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8ZGM3; -.
DR   EnsemblFungi; CAY82313; CAY82313; EC1118_1N9_0353g.
DR   HOGENOM; CLU_2279081_0_0_1; -.
DR   Proteomes; UP000000286; Chromosome XIV, Scaffold EC1118_1N9.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell wall; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..80
FT                   /note="Protein TOS6"
FT                   /id="PRO_0000402242"
FT   PROPEP          81..102
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000402243"
FT   LIPID           80
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   102 AA;  10170 MW;  2F8D02993704E1F5 CRC64;
     MKFSTLSTVA AIAAFASADS TSDGVTYVDV TTTPQSTTSM VSTVKTTSTP YTTSTIATLS
     TKSISSQANT TTHEISTYVG AAVKGSVAGM GAIMGAAAFA LL