ID   TOTA2_DROSI             Reviewed;         129 AA.
AC   B4R1Q5;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Protein Turandot A2;
DE   Flags: Precursor;
GN   Name=TotA2; ORFNames=GD19381;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1] {ECO:0000312|EMBL:EDX12164.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: A humoral factor that plays a role in stress tolerance; gives
CC       increased resistance to the lethal effects of bacterial challenge and
CC       stress. Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway
CC       in the fat body, upd3 in the hemocytes and Mekk1 in response to septic
CC       injury and consequent immune response (By similarity).
CC       {ECO:0000250|UniProtKB:Q8IN44}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IN44}.
CC       Note=Secreted from the fat body into the hemolymph. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Turandot family. {ECO:0000305}.
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DR   EMBL; CM000364; EDX12164.1; -; Genomic_DNA.
DR   RefSeq; XP_002102661.1; XM_002102625.2.
DR   AlphaFoldDB; B4R1Q5; -.
DR   SMR; B4R1Q5; -.
DR   EnsemblMetazoa; FBtr0219291; FBpp0217783; FBgn0190882.
DR   GeneID; 6727272; -.
DR   HOGENOM; CLU_152780_0_0_1; -.
DR   OMA; STSLMCF; -.
DR   PhylomeDB; B4R1Q5; -.
DR   Proteomes; UP000000304; Chromosome 3r.
DR   Bgee; FBgn0190882; Expressed in adult organism and 2 other tissues.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0034605; P:cellular response to heat; IEA:UniProt.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0009617; P:response to bacterium; ISS:UniProtKB.
DR   GO; GO:0009409; P:response to cold; ISS:UniProtKB.
DR   GO; GO:0009408; P:response to heat; ISS:UniProtKB.
DR   GO; GO:0009612; P:response to mechanical stimulus; ISS:UniProtKB.
DR   GO; GO:0006979; P:response to oxidative stress; ISS:UniProtKB.
DR   GO; GO:0009411; P:response to UV; ISS:UniProtKB.
DR   GO; GO:0009414; P:response to water deprivation; ISS:UniProtKB.
DR   InterPro; IPR010825; Turandot.
DR   Pfam; PF07240; Turandot; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Glycoprotein; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..129
FT                   /note="Protein Turandot A2"
FT                   /id="PRO_0000355140"
FT   CARBOHYD        49
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   129 AA;  14207 MW;  D699646E16E1D434 CRC64;
     MNSSTSLMCF ALLLISPLCM GYSDEDREAD SRRIAEIIQN AQDDDAKINS TQELLDIYRR
     LYPSLSLEDR ENIDKFVNEH TDAIVIDGVP IQGGRKAKII GKIVSPAAKG LAVGFFEELG
     SKIAQLFTG