TOTB_DROME
ID TOTB_DROME Reviewed; 138 AA.
AC Q9VDH4; Q962E0;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Protein Turandot B;
DE Flags: Precursor;
GN Name=TotB {ECO:0000312|EMBL:AAF55819.1, ECO:0000312|FlyBase:FBgn0038838};
GN ORFNames=CG5609;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK64521.1}
RP NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RC STRAIN=Canton-S {ECO:0000312|EMBL:AAK64521.1};
RX PubMed=11409894; DOI=10.1006/bbrc.2001.5067;
RA Ekengren S., Hultmark D.;
RT "A family of Turandot-related genes in the humoral stress response of
RT Drosophila.";
RL Biochem. Biophys. Res. Commun. 284:998-1003(2001).
RN [2] {ECO:0000312|EMBL:AAF55819.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAF55819.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000312|EMBL:AAM50911.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAM50911.1};
RC TISSUE=Larva {ECO:0000269|PubMed:12537569}, and
RC Pupae {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: A humoral factor that may play a role in stress tolerance.
CC {ECO:0000269|PubMed:11409894}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11409894,
CC ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in late stage embryos. Disappears by
CC early larval states and reappears in the third larval instar.
CC Subsequently maintained throughout pupal development until adulthood.
CC {ECO:0000269|PubMed:11409894}.
CC -!- INDUCTION: By a variety of stressful conditions including bacterial
CC infection, heat shock and exposure to ultraviolet light.
CC {ECO:0000269|PubMed:11409894}.
CC -!- SIMILARITY: Belongs to the Turandot family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK64521.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY035988; AAK64521.1; ALT_SEQ; mRNA.
DR EMBL; AE014297; AAF55819.1; -; Genomic_DNA.
DR EMBL; AY119051; AAM50911.1; -; mRNA.
DR RefSeq; NP_524422.1; NM_079698.3.
DR AlphaFoldDB; Q9VDH4; -.
DR IntAct; Q9VDH4; 5.
DR STRING; 7227.FBpp0083380; -.
DR PaxDb; Q9VDH4; -.
DR DNASU; 42474; -.
DR EnsemblMetazoa; FBtr0083973; FBpp0083380; FBgn0038838.
DR GeneID; 42474; -.
DR KEGG; dme:Dmel_CG5609; -.
DR UCSC; CG5609-RA; d. melanogaster.
DR CTD; 42474; -.
DR FlyBase; FBgn0038838; TotB.
DR VEuPathDB; VectorBase:FBgn0038838; -.
DR GeneTree; ENSGT00940000176310; -.
DR HOGENOM; CLU_152780_0_0_1; -.
DR InParanoid; Q9VDH4; -.
DR OMA; CSAYSNQ; -.
DR OrthoDB; 1607084at2759; -.
DR PhylomeDB; Q9VDH4; -.
DR BioGRID-ORCS; 42474; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42474; -.
DR PRO; PR:Q9VDH4; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038838; Expressed in arthropod fat body and 8 other tissues.
DR Genevisible; Q9VDH4; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0034605; P:cellular response to heat; IEP:FlyBase.
DR GO; GO:0034644; P:cellular response to UV; IEP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEP:FlyBase.
DR GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR GO; GO:0009411; P:response to UV; IDA:UniProtKB.
DR InterPro; IPR010825; Turandot.
DR Pfam; PF07240; Turandot; 1.
PE 2: Evidence at transcript level;
KW Immunity; Innate immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..138
FT /note="Protein Turandot B"
FT /id="PRO_0000354980"
SQ SEQUENCE 138 AA; 15594 MW; 1762A36B67581092 CRC64;
MNFKTSLICF ALLLIGTLCS AYSNQERQRD SRRVAEIMRT SWDDNTKIKR IQELLTIYNR
MAPSLRPDER ARMDRFISGY TGEIMVDGVP SQGGARRIFK KILSPAAKSV ATGFFTELGA
SLASILTSWF PANTERNH
