ID   TOTC_DROME              Reviewed;         129 AA.
AC   Q8IN43; Q962D9;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Protein Turandot C;
DE   Flags: Precursor;
GN   Name=TotC {ECO:0000312|EMBL:AAN13841.1, ECO:0000312|FlyBase:FBgn0044812};
GN   ORFNames=CG31508;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAK64522.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DEVELOPMENTAL STAGE, AND
RP   INDUCTION.
RC   STRAIN=Canton-S {ECO:0000312|EMBL:AAK64522.1};
RX   PubMed=11409894; DOI=10.1006/bbrc.2001.5067;
RA   Ekengren S., Hultmark D.;
RT   "A family of Turandot-related genes in the humoral stress response of
RT   Drosophila.";
RL   Biochem. Biophys. Res. Commun. 284:998-1003(2001).
RN   [2] {ECO:0000312|EMBL:AAN13841.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:AAN13841.1}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000312|EMBL:AAY55721.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA   Park S., Wan K.H., Yu C., Celniker S.E.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: A humoral factor that may play a role in stress tolerance.
CC       {ECO:0000269|PubMed:11409894}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11409894,
CC       ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late stage embryos. Disappears by
CC       early larval states and reappears in the third larval instar.
CC       Subsequently maintained throughout pupal development until adulthood.
CC       {ECO:0000269|PubMed:11409894}.
CC   -!- INDUCTION: By a variety of stressful conditions including bacterial
CC       infection, heat shock and exposure to ultraviolet light.
CC       {ECO:0000269|PubMed:11409894}.
CC   -!- SIMILARITY: Belongs to the Turandot family. {ECO:0000255}.
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DR   EMBL; AY035989; AAK64522.1; -; mRNA.
DR   EMBL; AE014297; AAN13841.1; -; Genomic_DNA.
DR   EMBL; BT023305; AAY55721.1; -; mRNA.
DR   RefSeq; NP_536779.2; NM_080518.3.
DR   AlphaFoldDB; Q8IN43; -.
DR   SMR; Q8IN43; -.
DR   BioGRID; 72896; 1.
DR   IntAct; Q8IN43; 1.
DR   STRING; 7227.FBpp0083379; -.
DR   PaxDb; Q8IN43; -.
DR   PRIDE; Q8IN43; -.
DR   DNASU; 117462; -.
DR   EnsemblMetazoa; FBtr0083972; FBpp0083379; FBgn0044812.
DR   GeneID; 117462; -.
DR   KEGG; dme:Dmel_CG31508; -.
DR   UCSC; CG31508-RA; d. melanogaster.
DR   CTD; 117462; -.
DR   FlyBase; FBgn0044812; TotC.
DR   VEuPathDB; VectorBase:FBgn0044812; -.
DR   GeneTree; ENSGT00940000176310; -.
DR   HOGENOM; CLU_152780_0_0_1; -.
DR   InParanoid; Q8IN43; -.
DR   OMA; RKTKYAG; -.
DR   OrthoDB; 1607084at2759; -.
DR   PhylomeDB; Q8IN43; -.
DR   GenomeRNAi; 117462; -.
DR   PRO; PR:Q8IN43; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0044812; Expressed in head capsule and 17 other tissues.
DR   ExpressionAtlas; Q8IN43; differential.
DR   Genevisible; Q8IN43; DM.
DR   GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0034605; P:cellular response to heat; IEP:FlyBase.
DR   GO; GO:0034644; P:cellular response to UV; IEP:FlyBase.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0009617; P:response to bacterium; IEP:FlyBase.
DR   GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR   GO; GO:0006979; P:response to oxidative stress; IDA:UniProtKB.
DR   GO; GO:0009411; P:response to UV; IDA:UniProtKB.
DR   InterPro; IPR010825; Turandot.
DR   Pfam; PF07240; Turandot; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Innate immunity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..129
FT                   /note="Protein Turandot C"
FT                   /id="PRO_0000354984"
SQ   SEQUENCE   129 AA;  14296 MW;  4078FF39507B0D0A CRC64;
     MNASISLLCL ALLLISPFCL GYSDEERESD SLRVAEIIRT SNDAESKINR TQELLDIFRR
     LTPTLSPEQR EKIERSIQEH TDEILIDGVP SQGGRKTKYV GKILSPVAQG LAVGFFEELG
     GSLSRLFTG