TOTE_DROME
ID TOTE_DROME Reviewed; 134 AA.
AC Q8INV7; Q962E1; Q962F4;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein Turandot E;
DE AltName: Full=Protein Victoria {ECO:0000303|PubMed:11409894};
DE Flags: Precursor;
GN Name=Victoria {ECO:0000312|EMBL:AAN11059.2};
GN Synonyms=TotE {ECO:0000303|PubMed:11409894}; ORFNames=CG33117;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAN11059.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAN11059.2}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAK58889.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2-134.
RA Petersen U.-M., Mathey-Prevot B., Perrimon N.;
RT "Victoria, a putative secreted protein.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAK64520.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 4-134, POSSIBLE FUNCTION, DEVELOPMENTAL
RP STAGE, AND INDUCTION.
RC STRAIN=Canton-S {ECO:0000312|EMBL:AAK64520.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:11409894};
RX PubMed=11409894; DOI=10.1006/bbrc.2001.5067;
RA Ekengren S., Hultmark D.;
RT "A family of Turandot-related genes in the humoral stress response of
RT Drosophila.";
RL Biochem. Biophys. Res. Commun. 284:998-1003(2001).
CC -!- FUNCTION: A humoral factor that may play a role in stress tolerance.
CC {ECO:0000269|PubMed:11409894}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11409894,
CC ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the third larval instar and
CC maintained through to early pupal development.
CC {ECO:0000269|PubMed:11409894}.
CC -!- INDUCTION: By a variety of stressful conditions including bacterial
CC infection, heat shock and exposure to ultraviolet light.
CC {ECO:0000269|PubMed:11409894}.
CC -!- SIMILARITY: Belongs to the Turandot family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK58889.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAK64520.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAN11059.2; -; Genomic_DNA.
DR EMBL; AY034880; AAK58889.1; ALT_INIT; mRNA.
DR EMBL; AY035987; AAK64520.1; ALT_SEQ; mRNA.
DR RefSeq; NP_788077.2; NM_176063.3.
DR AlphaFoldDB; Q8INV7; -.
DR IntAct; Q8INV7; 2.
DR PaxDb; Q8INV7; -.
DR DNASU; 35275; -.
DR EnsemblMetazoa; FBtr0081309; FBpp0080844; FBgn0053117.
DR GeneID; 35275; -.
DR KEGG; dme:Dmel_CG33117; -.
DR UCSC; CG33117-RA; d. melanogaster.
DR CTD; 35275; -.
DR FlyBase; FBgn0053117; Victoria.
DR VEuPathDB; VectorBase:FBgn0053117; -.
DR GeneTree; ENSGT00540000073707; -.
DR HOGENOM; CLU_158853_0_0_1; -.
DR OMA; GHCQSEA; -.
DR OrthoDB; 1616315at2759; -.
DR PhylomeDB; Q8INV7; -.
DR BioGRID-ORCS; 35275; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35275; -.
DR PRO; PR:Q8INV7; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0053117; Expressed in arthropod fat body and 6 other tissues.
DR ExpressionAtlas; Q8INV7; baseline and differential.
DR Genevisible; Q8INV7; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0034605; P:cellular response to heat; IEP:FlyBase.
DR GO; GO:0034644; P:cellular response to UV; IEP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEP:FlyBase.
DR GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR InterPro; IPR010825; Turandot.
DR Pfam; PF07240; Turandot; 1.
PE 2: Evidence at transcript level;
KW Immunity; Innate immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..134
FT /note="Protein Turandot E"
FT /id="PRO_0000354988"
FT CONFLICT 21
FT /note="Q -> K (in Ref. 4; AAK64520)"
FT /evidence="ECO:0000305"
FT CONFLICT 56..59
FT /note="Missing (in Ref. 4; AAK64520)"
FT /evidence="ECO:0000305"
FT CONFLICT 71
FT /note="T -> A (in Ref. 4; AAK64520)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="Y -> C (in Ref. 4; AAK64520)"
FT /evidence="ECO:0000305"
FT CONFLICT 88
FT /note="Q -> E (in Ref. 3; AAK58889)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 134 AA; 14736 MW; 60D932078BCE3A26 CRC64;
MSNTRTVHSS TSISKMNSAL QISCLLVVLG CLLGSGHCQS EAEFAAKSRE IAQVFGNPSV
DKYTKARNLP TLIAFYEKYS SRLRLTPQER ISINNAMRQY KAQRNQQVDG VSAQGGWLSD
IIKTAISIIV KAVE
