TOTF_DROME
ID TOTF_DROME Reviewed; 125 AA.
AC Q9VIR2; Q962D8;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 3.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Protein Turandot F;
DE Flags: Precursor;
GN Name=TotF {ECO:0000312|EMBL:AAF53853.3}; ORFNames=CG31691;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK64524.1}
RP NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RC STRAIN=Canton-S {ECO:0000312|EMBL:AAK64524.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:11409894};
RX PubMed=11409894; DOI=10.1006/bbrc.2001.5067;
RA Ekengren S., Hultmark D.;
RT "A family of Turandot-related genes in the humoral stress response of
RT Drosophila.";
RL Biochem. Biophys. Res. Commun. 284:998-1003(2001).
RN [2] {ECO:0000312|EMBL:AAF53853.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAF53853.3}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: A humoral factor that may play a role in stress tolerance.
CC {ECO:0000269|PubMed:11409894}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11409894,
CC ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in late embryos and disappeared by early
CC larval states to reappear in the early pupae.
CC {ECO:0000269|PubMed:11409894}.
CC -!- INDUCTION: By a variety of stressful conditions including bacterial
CC infection, heat shock and exposure to ultraviolet light.
CC {ECO:0000269|PubMed:11409894}.
CC -!- SIMILARITY: Belongs to the Turandot family. {ECO:0000255}.
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DR EMBL; AY035991; AAK64524.1; -; mRNA.
DR EMBL; AE014134; AAF53853.3; -; Genomic_DNA.
DR RefSeq; NP_536780.3; NM_080519.4.
DR AlphaFoldDB; Q9VIR2; -.
DR SMR; Q9VIR2; -.
DR STRING; 7227.FBpp0080845; -.
DR PaxDb; Q9VIR2; -.
DR DNASU; 117461; -.
DR EnsemblMetazoa; FBtr0081310; FBpp0080845; FBgn0044811.
DR GeneID; 117461; -.
DR KEGG; dme:Dmel_CG31691; -.
DR UCSC; CG31691-RA; d. melanogaster.
DR CTD; 117461; -.
DR FlyBase; FBgn0044811; TotF.
DR VEuPathDB; VectorBase:FBgn0044811; -.
DR GeneTree; ENSGT00540000073707; -.
DR HOGENOM; CLU_158853_0_0_1; -.
DR OMA; YRAQNNQ; -.
DR OrthoDB; 1605521at2759; -.
DR PhylomeDB; Q9VIR2; -.
DR BioGRID-ORCS; 117461; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 117461; -.
DR PRO; PR:Q9VIR2; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0044811; Expressed in arthropod fat body and 7 other tissues.
DR ExpressionAtlas; Q9VIR2; baseline.
DR Genevisible; Q9VIR2; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0034605; P:cellular response to heat; IEP:FlyBase.
DR GO; GO:0034644; P:cellular response to UV; IEP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IDA:UniProtKB.
DR GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR GO; GO:0009411; P:response to UV; IDA:UniProtKB.
DR InterPro; IPR010825; Turandot.
DR Pfam; PF07240; Turandot; 1.
PE 2: Evidence at transcript level;
KW Immunity; Innate immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..125
FT /note="Protein Turandot F"
FT /id="PRO_0000354992"
FT CONFLICT 50..52
FT /note="SRN -> TRK (in Ref. 1; AAK64524)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="I -> V (in Ref. 1; AAK64524)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 125 AA; 13975 MW; 6227DCBD82294771 CRC64;
MKTVILFGFL LALLGYLEAE HAQSDPEFTA KARQMLAVFG NSEVDRYTKS RNLPALIEFY
EKYSSRLPLT VQDRTYANNV IRRYRAHNNQ QVDGVPAQGG VGVVFALLLP FAVSIVEGIA
KAIRE
