TOTM_DROME
ID TOTM_DROME Reviewed; 131 AA.
AC Q9VMR8; Q962D7;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein Turandot M;
DE Flags: Precursor;
GN Name=TotM {ECO:0000312|EMBL:AAF52243.2}; ORFNames=CG14027;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK64525.1}
RP NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RC STRAIN=Canton-S {ECO:0000312|EMBL:AAK64525.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:11409894};
RX PubMed=11409894; DOI=10.1006/bbrc.2001.5067;
RA Ekengren S., Hultmark D.;
RT "A family of Turandot-related genes in the humoral stress response of
RT Drosophila.";
RL Biochem. Biophys. Res. Commun. 284:998-1003(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=16611243; DOI=10.1111/j.1365-2443.2006.00953.x;
RA Brun S., Vidal S., Spellman P., Takahashi K., Tricoire H., Lemaitre B.;
RT "The MAPKKK Mekk1 regulates the expression of Turandot stress genes in
RT response to septic injury in Drosophila.";
RL Genes Cells 11:397-407(2006).
CC -!- FUNCTION: A humoral factor that may play a role in stress tolerance.
CC Requires Mekk1 expression in the fat body to regulate response to
CC septic injury and consequent immune response.
CC {ECO:0000269|PubMed:11409894, ECO:0000269|PubMed:16611243}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11409894,
CC ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed at very low levels.
CC {ECO:0000269|PubMed:11409894}.
CC -!- INDUCTION: By a variety of stressful conditions including bacterial
CC infection and heat shock. {ECO:0000269|PubMed:11409894}.
CC -!- SIMILARITY: Belongs to the Turandot family. {ECO:0000255}.
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DR EMBL; AY035992; AAK64525.1; -; mRNA.
DR EMBL; AE014134; AAF52243.2; -; Genomic_DNA.
DR RefSeq; NP_001245887.1; NM_001258958.1.
DR RefSeq; NP_523482.1; NM_078758.3.
DR AlphaFoldDB; Q9VMR8; -.
DR IntAct; Q9VMR8; 2.
DR STRING; 7227.FBpp0078708; -.
DR PaxDb; Q9VMR8; -.
DR DNASU; 33764; -.
DR EnsemblMetazoa; FBtr0079073; FBpp0078708; FBgn0031701.
DR EnsemblMetazoa; FBtr0307036; FBpp0297879; FBgn0031701.
DR GeneID; 33764; -.
DR KEGG; dme:Dmel_CG14027; -.
DR UCSC; CG14027-RA; d. melanogaster.
DR CTD; 33764; -.
DR FlyBase; FBgn0031701; TotM.
DR VEuPathDB; VectorBase:FBgn0031701; -.
DR GeneTree; ENSGT00540000073707; -.
DR HOGENOM; CLU_158853_0_0_1; -.
DR OMA; FVTEKQR; -.
DR OrthoDB; 1519974at2759; -.
DR PhylomeDB; Q9VMR8; -.
DR BioGRID-ORCS; 33764; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33764; -.
DR PRO; PR:Q9VMR8; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031701; Expressed in adult abdomen and 16 other tissues.
DR ExpressionAtlas; Q9VMR8; baseline and differential.
DR Genevisible; Q9VMR8; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0034605; P:cellular response to heat; IEP:FlyBase.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEP:FlyBase.
DR GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR InterPro; IPR010825; Turandot.
DR Pfam; PF07240; Turandot; 1.
PE 2: Evidence at transcript level;
KW Immunity; Innate immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..131
FT /note="Protein Turandot M"
FT /id="PRO_0000354996"
SQ SEQUENCE 131 AA; 14967 MW; 26B14C3BD2F7636B CRC64;
MNPTIYLSCL MVFSVFLLGK VNAENEDEFV TEKQRLFSVY GDSSVDEATK YRNIDSLVTF
YDKYFTRLQL KPDLNTRAHD LLRRYKEENA RVVLVDGTPA QGGFWLPLVK LLIVQLGVEI
ASEGVKRAIE S
