ID   TOTM_DROYA              Reviewed;         131 AA.
AC   B4P071;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Protein Turandot M;
DE   Flags: Precursor;
GN   Name=TotM {ECO:0000250|UniProtKB:Q9VMR8}; ORFNames=GE25388;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1] {ECO:0000312|EMBL:EDW88936.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000312|EMBL:EDW88936.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: A humoral factor that may play a role in stress tolerance.
CC       Requires Mekk1 expression in the fat body to regulate response to
CC       septic injury and consequent immune response (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VMR8}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9VMR8}.
CC   -!- SIMILARITY: Belongs to the Turandot family. {ECO:0000255}.
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DR   EMBL; CM000157; EDW88936.1; -; Genomic_DNA.
DR   RefSeq; XP_002089224.2; XM_002089188.2.
DR   AlphaFoldDB; B4P071; -.
DR   SMR; B4P071; -.
DR   EnsemblMetazoa; FBtr0271906; FBpp0270398; FBgn0242465.
DR   GeneID; 6528159; -.
DR   KEGG; dya:Dyak_GE25388; -.
DR   HOGENOM; CLU_158853_0_0_1; -.
DR   OMA; RYRNVDD; -.
DR   OrthoDB; 1519974at2759; -.
DR   PhylomeDB; B4P071; -.
DR   Proteomes; UP000002282; Chromosome 2L.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0034605; P:cellular response to heat; IEA:EnsemblMetazoa.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:EnsemblMetazoa.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0009408; P:response to heat; ISS:UniProtKB.
DR   InterPro; IPR010825; Turandot.
DR   Pfam; PF07240; Turandot; 1.
PE   3: Inferred from homology;
KW   Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..131
FT                   /note="Protein Turandot M"
FT                   /id="PRO_0000354998"
SQ   SEQUENCE   131 AA;  14881 MW;  E93922A00AACD5F6 CRC64;
     MNPTVYLSCL VVFSLFYLGK AQAENDDEFA TEKQRLLRVY GDSSVDEATR YRNVDDLVKF
     YDKYSTLLPL KPDLTQRAQD LVRRYKEESA RVVLVDGAPA QGGFWLPLVK LLIVQLGVEI
     ASEGFKRAIE S