ID   TOTX_DROME              Reviewed;         142 AA.
AC   Q8IN41; Q962D6;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Protein Turandot X;
DE   Flags: Precursor;
GN   Name=TotX {ECO:0000312|EMBL:AAN13843.1, ECO:0000312|FlyBase:FBgn0044810};
GN   ORFNames=CG31193;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAK64526.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DEVELOPMENTAL STAGE, AND
RP   INDUCTION.
RC   STRAIN=Canton-S {ECO:0000312|EMBL:AAK64526.1};
RC   TISSUE=Embryo {ECO:0000269|PubMed:11409894};
RX   PubMed=11409894; DOI=10.1006/bbrc.2001.5067;
RA   Ekengren S., Hultmark D.;
RT   "A family of Turandot-related genes in the humoral stress response of
RT   Drosophila.";
RL   Biochem. Biophys. Res. Commun. 284:998-1003(2001).
RN   [2] {ECO:0000312|EMBL:AAN13843.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:AAN13843.1}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000312|EMBL:AAY55729.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA   Park S., Wan K.H., Yu C., Celniker S.E.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: A humoral factor that may play a role in stress tolerance.
CC       {ECO:0000269|PubMed:11409894}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11409894,
CC       ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at very low levels.
CC       {ECO:0000269|PubMed:11409894}.
CC   -!- INDUCTION: By a variety of stressful conditions including bacterial
CC       infection, heat shock and paraquat feeding.
CC       {ECO:0000269|PubMed:11409894}.
CC   -!- SIMILARITY: Belongs to the Turandot family. {ECO:0000255}.
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DR   EMBL; AY035993; AAK64526.1; -; mRNA.
DR   EMBL; AE014297; AAN13843.1; -; Genomic_DNA.
DR   EMBL; BT023313; AAY55729.1; -; mRNA.
DR   RefSeq; NP_536781.2; NM_080520.3.
DR   AlphaFoldDB; Q8IN41; -.
DR   STRING; 7227.FBpp0083389; -.
DR   PaxDb; Q8IN41; -.
DR   PRIDE; Q8IN41; -.
DR   DNASU; 117460; -.
DR   EnsemblMetazoa; FBtr0083985; FBpp0083389; FBgn0044810.
DR   GeneID; 117460; -.
DR   KEGG; dme:Dmel_CG31193; -.
DR   UCSC; CG31193-RA; d. melanogaster.
DR   CTD; 117460; -.
DR   FlyBase; FBgn0044810; TotX.
DR   VEuPathDB; VectorBase:FBgn0044810; -.
DR   HOGENOM; CLU_1817777_0_0_1; -.
DR   InParanoid; Q8IN41; -.
DR   OMA; QFERFIH; -.
DR   OrthoDB; 1457707at2759; -.
DR   PhylomeDB; Q8IN41; -.
DR   BioGRID-ORCS; 117460; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 117460; -.
DR   PRO; PR:Q8IN41; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0044810; Expressed in head capsule and 12 other tissues.
DR   ExpressionAtlas; Q8IN41; baseline and differential.
DR   Genevisible; Q8IN41; DM.
DR   GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0034605; P:cellular response to heat; IEP:FlyBase.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEP:FlyBase.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0009617; P:response to bacterium; IDA:UniProtKB.
DR   GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR   GO; GO:0006979; P:response to oxidative stress; IDA:UniProtKB.
DR   InterPro; IPR010825; Turandot.
DR   Pfam; PF07240; Turandot; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Innate immunity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..142
FT                   /note="Protein Turandot X"
FT                   /id="PRO_0000355000"
FT   CONFLICT        102
FT                   /note="S -> A (in Ref. 1; AAK64526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        117
FT                   /note="R -> Q (in Ref. 1; AAK64526)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   142 AA;  16369 MW;  C656F4F74B6C55CB CRC64;
     MGLSIGSLLI CVFLGIVPFA TANTNSSSYE EHRNYLLNIF HNPFVNDSIK EKNIPQLIAF
     YQRYPTDVPL SDADRQQFER FIHDYREYRA VLVDGAPPQG GSFGNIFGHF LGRVGTRYIS
     SLFNKKREER KSNHAYIIED YN