TOTZ_DROME
ID TOTZ_DROME Reviewed; 147 AA.
AC Q8IN42; Q962D5;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Protein Turandot Z;
DE Flags: Precursor;
GN Name=TotZ {ECO:0000312|EMBL:AAN13842.1}; ORFNames=CG31507;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK64527.1}
RP NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RC STRAIN=Canton-S {ECO:0000312|EMBL:AAK64527.1};
RC TISSUE=Pupae {ECO:0000269|PubMed:11409894};
RX PubMed=11409894; DOI=10.1006/bbrc.2001.5067;
RA Ekengren S., Hultmark D.;
RT "A family of Turandot-related genes in the humoral stress response of
RT Drosophila.";
RL Biochem. Biophys. Res. Commun. 284:998-1003(2001).
RN [2] {ECO:0000312|EMBL:AAN13842.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAN13842.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: A humoral factor that may play a role in stress tolerance.
CC {ECO:0000269|PubMed:11409894}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11409894,
CC ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the early pupae.
CC {ECO:0000269|PubMed:11409894}.
CC -!- INDUCTION: By a variety of stressful conditions such as bacterial
CC infection, heat shock, paraquat feeding and exposure to ultraviolet
CC light. {ECO:0000269|PubMed:11409894}.
CC -!- SIMILARITY: Belongs to the Turandot family. {ECO:0000255}.
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DR EMBL; AY035994; AAK64527.1; -; mRNA.
DR EMBL; AE014297; AAN13842.1; -; Genomic_DNA.
DR RefSeq; NP_536782.2; NM_080521.3.
DR AlphaFoldDB; Q8IN42; -.
DR STRING; 7227.FBpp0083381; -.
DR PaxDb; Q8IN42; -.
DR DNASU; 117459; -.
DR EnsemblMetazoa; FBtr0083974; FBpp0083381; FBgn0044809.
DR GeneID; 117459; -.
DR KEGG; dme:Dmel_CG31507; -.
DR UCSC; CG31507-RA; d. melanogaster.
DR CTD; 117459; -.
DR FlyBase; FBgn0044809; TotZ.
DR VEuPathDB; VectorBase:FBgn0044809; -.
DR GeneTree; ENSGT00940000176310; -.
DR HOGENOM; CLU_1760725_0_0_1; -.
DR InParanoid; Q8IN42; -.
DR OMA; FKRKTMV; -.
DR OrthoDB; 1542994at2759; -.
DR PhylomeDB; Q8IN42; -.
DR BioGRID-ORCS; 117459; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 117459; -.
DR PRO; PR:Q8IN42; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0044809; Expressed in pupa and 1 other tissue.
DR ExpressionAtlas; Q8IN42; differential.
DR Genevisible; Q8IN42; DM.
DR GO; GO:0005576; C:extracellular region; ISM:FlyBase.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0034605; P:cellular response to heat; IEP:FlyBase.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEP:FlyBase.
DR GO; GO:0034644; P:cellular response to UV; IEP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEP:FlyBase.
DR GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR GO; GO:0006979; P:response to oxidative stress; IDA:UniProtKB.
DR GO; GO:0009411; P:response to UV; IDA:UniProtKB.
DR InterPro; IPR010825; Turandot.
DR Pfam; PF07240; Turandot; 1.
PE 2: Evidence at transcript level;
KW Immunity; Innate immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..147
FT /note="Protein Turandot Z"
FT /id="PRO_0000355006"
FT CONFLICT 15
FT /note="I -> F (in Ref. 1; AAK64527)"
FT /evidence="ECO:0000305"
FT CONFLICT 19
FT /note="G -> E (in Ref. 1; AAK64527)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 147 AA; 16179 MW; 450A92CEA5FF0E45 CRC64;
MYFAIRLSFV LAVLICLTGN GSARMLDADR NRLQQLQIRS QQSADANTQV DIAYEVIGIY
DKYKGQGGSN VLREAQLNSQ VNDFKRKTMV IDGVPAQGGV WGILGAIKKA ADAVPDNVKK
DAENLVKSST KVLVRGIYDY LMGKMKH
