ID   TOX1_BORPA              Reviewed;         269 AA.
AC   Q7W2U8;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Pertussis toxin subunit 1 homolog;
DE   Flags: Precursor;
GN   Name=ptxA; OrderedLocusNames=BPP4304;
OS   Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12822 / ATCC BAA-587 / NCTC 13253;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
RN   [2]
RP   TRANSCRIPTIONAL SILENCING.
RC   STRAIN=ATCC 9305;
RX   PubMed=3584073; DOI=10.1128/jb.169.6.2847-2853.1987;
RA   Arico B., Rappuoli R.;
RT   "Bordetella parapertussis and Bordetella bronchiseptica contain
RT   transcriptionally silent pertussis toxin genes.";
RL   J. Bacteriol. 169:2847-2853(1987).
RN   [3]
RP   POSSIBLE EXPRESSION OF PTL AND PTX PROTEINS UNDER CONDITIONS DIFFERENT FROM
RP   B.PERTUSSIS EXPRESSION CONDITIONS.
RC   STRAIN=10978, and 13449;
RX   PubMed=8926063; DOI=10.1128/iai.64.10.4020-4026.1996;
RA   Hausman S.Z., Cherry J.D., Heininger U., Wirsing von Koenig C.H.,
RA   Burns D.L.;
RT   "Analysis of proteins encoded by the ptx and ptl genes of Bordetella
RT   bronchiseptica and Bordetella parapertussis.";
RL   Infect. Immun. 64:4020-4026(1996).
CC   -!- SIMILARITY: Belongs to the bacterial exotoxin subunit A family.
CC       {ECO:0000305}.
CC   -!- CAUTION: B.parapertussis and B.bronchiseptica seem not to produce the
CC       pertussis toxin (S1, S2, S4, S5 and S3) and Ptl proteins (PtlA, PtlB,
CC       PtlC, PtlD, PtlE, PtlF, PtlG, PtlH and PtlI) in vivo due to changes in
CC       the promoter region of the ptx-ptl operon. However, it is possible that
CC       their promoter is active under certain, as-yet-undefined conditions and
CC       that B.parapertussis and B.bronchiseptica are therefore capable of
CC       producing these proteins. {ECO:0000305}.
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DR   EMBL; BX640436; CAE39582.1; -; Genomic_DNA.
DR   RefSeq; WP_010929490.1; NC_002928.3.
DR   AlphaFoldDB; Q7W2U8; -.
DR   SMR; Q7W2U8; -.
DR   PRIDE; Q7W2U8; -.
DR   EnsemblBacteria; CAE39582; CAE39582; BPP4304.
DR   KEGG; bpa:BPP4304; -.
DR   HOGENOM; CLU_1145818_0_0_4; -.
DR   OMA; YIYQIRA; -.
DR   Proteomes; UP000001421; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro.
DR   InterPro; IPR003898; Borpert_toxA.
DR   Pfam; PF02917; Pertussis_S1; 1.
DR   PRINTS; PR01395; BORPETOXINA.
PE   3: Inferred from homology;
KW   Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..269
FT                   /note="Pertussis toxin subunit 1 homolog"
FT                   /id="PRO_0000251142"
SQ   SEQUENCE   269 AA;  30065 MW;  1C94946453C30E72 CRC64;
     MRCTRAIRQT ARTGWLTWLA ILAVTAPMTS PAWADDPPAT VYRYDSRPPE DVFQNGFTAW
     GNNDNVLEHL TGRSCQVGSS NSAFVSTSSS RRYTEVYLEH RMQEAVEAER AGRGTGHFIG
     YIYEIRADNN FYGAASSYFE YVDTYGDNAG RILAGALATY QSEYLAHRRI PPENIRTVTR
     VYHNGITGET TTTEYPNLRY VSQQTRANTN PYTSRRSTAS IVGTLVRMAP VTGACMARQA
     ESPEAMAAWS ERTGEAMVLV YYESIAYSF