ID   TOX4A_XENLA             Reviewed;         597 AA.
AC   Q6DJL0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=TOX high mobility group box family member 4-A;
GN   Name=tox4-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; BC075166; AAH75166.1; -; mRNA.
DR   RefSeq; NP_001086364.1; NM_001092895.1.
DR   AlphaFoldDB; Q6DJL0; -.
DR   SMR; Q6DJL0; -.
DR   GeneID; 444793; -.
DR   KEGG; xla:444793; -.
DR   CTD; 444793; -.
DR   Xenbase; XB-GENE-993810; tox4.S.
DR   OrthoDB; 1465513at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 444793; Expressed in testis and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0072357; C:PTW/PP1 phosphatase complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR037985; TOX4.
DR   PANTHER; PTHR45781:SF2; PTHR45781:SF2; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..597
FT                   /note="TOX high mobility group box family member 4-A"
FT                   /id="PRO_0000364350"
FT   DNA_BIND        222..290
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          160..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           212..217
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   597 AA;  64178 MW;  0577AAF42CEF271E CRC64;
     MEFPGSSDNY LTITGPGHPF LTGTETFHTP SLGDEEFEIP PISLDSDPSL AVSDVVGHFD
     DLSDPSGVQD EGFATQYGVQ TLDMPVEMTH EVMDQTGGLL GAGLALDLDH PIVTPYSANP
     PVTIDVSMTD MSSGILGHSQ LTTIDQSELS SQLGLSLGGG AILHPVQSPE DHLSPTPSPT
     SSLHDEDMED FRRITAPKSI IVEQAKKPKT PKKKKKKDPN EPQKPLSAYA LFFRDTQAAI
     KGQNPNATFG EVSKIVASMW DSLGEEQKQV YKRKTEAAKK EYLKALALYK ANQLSQVAVD
     TVDLDPPAVP ALLSESPVPS PSIVTATSIP ECASSPSAPS PPSQTVAAPQ QSIAKIIISK
     QILPAGLSST SIAMSQGVVT VIPATVVTSR GLPLSQLQPS PQAQRITRSV LQAAMQMPPR
     LQPPPLQQMQ QPPRLQQMAP AQQPSITILQ SPPPLQPMQK VRLSLQQPPP LQIKIIPPPL
     QPQPQVVQVQ NQSLSVINVP TSFEAPASPP EQLEVLPEVV QEESPPPQMD VELVSSSPPP
     SLSPQPQCVR SGCENPPVEC KDWDNEYCSN ECVVRHCRDT FMAWVSTRSQ GTLASVK