ID   TOX4B_XENLA             Reviewed;         594 AA.
AC   Q6IRR0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=TOX high mobility group box family member 4-B;
GN   Name=tox4-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; BC070618; AAH70618.1; -; mRNA.
DR   RefSeq; NP_001084977.1; NM_001091508.1.
DR   AlphaFoldDB; Q6IRR0; -.
DR   SMR; Q6IRR0; -.
DR   DNASU; 432037; -.
DR   GeneID; 432037; -.
DR   KEGG; xla:432037; -.
DR   CTD; 432037; -.
DR   Xenbase; XB-GENE-6256289; tox4.L.
DR   OMA; TMSQEGM; -.
DR   OrthoDB; 1039184at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 432037; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0072357; C:PTW/PP1 phosphatase complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR037985; TOX4.
DR   PANTHER; PTHR45781:SF2; PTHR45781:SF2; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..594
FT                   /note="TOX high mobility group box family member 4-B"
FT                   /id="PRO_0000364351"
FT   DNA_BIND        222..290
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          160..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           212..217
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        529..545
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   594 AA;  63679 MW;  CAFA2B4FD556708D CRC64;
     MEFPGSSDNY LTITGPGHPF LTGTETFHTP SLGDEEFEIP PISLDSDPSL AVSDVVGHFD
     DLADSSGVQD EGFAAQYGVQ TLDMPVEMAH EVMDQTGGLL GAGLAMDLDH PIVTPYSANP
     PVTIDVSMTD MSSGILGHGQ LTTIDQSELS SQLGLSLGGG TILHPVQSPD DHLSPTPSPT
     SSLHDEDMED FRRITAPKSI IVEQTKKPKT PKKKKKKDPN EPQKPLSAYA LFFRDTQAAI
     KGQNPNATFG EVSKIVASMW DSLGEEQKQV YKRKTEAAKK EYLKALALYK ANQLSQVAVD
     TVDLDPPAVP ALLSESPVPS PTVVTATSIP ECVSSPSVSS SPSQTVAAPQ QSIAKIIISK
     QILPAGQGST AIAMSQGMVT VIPATVVTSR GLPLAQLQPS PQAQRITRSV LQAAMQMPPR
     LQPPPLQQMQ QPPRLLQMAP AQQPSITILQ APPPLQPMQK VRLSLQPPPL QIKIIPPPLQ
     PQPQVVQVQN QSLSVINVPA SPEAPASPPE QLEVLPEVVQ EESPPPQMDV ELVSSSPPPS
     LSPQCVRSGC ENPPVECKDW DNEYCSNECV VKHCRDTFMS WIATRSQGTL APVK