ID   TOX4_XENTR              Reviewed;         597 AA.
AC   A4QNP0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=TOX high mobility group box family member 4;
GN   Name=tox4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; BC135950; AAI35951.1; -; mRNA.
DR   RefSeq; NP_001090624.1; NM_001097155.1.
DR   AlphaFoldDB; A4QNP0; -.
DR   SMR; A4QNP0; -.
DR   PaxDb; A4QNP0; -.
DR   DNASU; 395028; -.
DR   GeneID; 395028; -.
DR   KEGG; xtr:395028; -.
DR   CTD; 9878; -.
DR   Xenbase; XB-GENE-993803; tox4.
DR   eggNOG; KOG0381; Eukaryota.
DR   InParanoid; A4QNP0; -.
DR   OrthoDB; 1465513at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0072357; C:PTW/PP1 phosphatase complex; IEA:InterPro.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR037985; TOX4.
DR   PANTHER; PTHR45781:SF2; PTHR45781:SF2; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..597
FT                   /note="TOX high mobility group box family member 4"
FT                   /id="PRO_0000364352"
FT   DNA_BIND        222..290
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          160..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          520..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           212..217
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   597 AA;  64149 MW;  FF10105C09170BCF CRC64;
     MEFPGSSDNY LTITGPGHPF LTGTETFHTP SLGDEEFEIP PISLDSDPSL AVSDVVGHFD
     DLGDPSGVQD EGFATQYGVQ TLDMPVEMTH EVMDQTGGLL GAGLAMDLDH PIVTPYSANP
     PVTIDVSMTD MSSGILGHSQ LTTIDQSELS SQLGLSLGGG AILHPVQSPE DHLSPTPSPT
     SSLHDEDMED FRRITAPKNI IVEQAKKPKT PKKKKKKDPN EPQKPLSAYA LFFRDTQAAI
     KGQNPNATFG EVSKIVASMW DSLGEEQKQV YKRKTEAAKK EYLKALALYK ANQLSQVAVD
     TVDLDPPAVP ALLSESPVPS PSVVTATSIP ECVSSPSAPS PPSQTVALPQ QSIAKIIISK
     QILPAGQNPT SIALSQGVVT VIPATVVTSR GLPLAQLQPS PQAQRVTRSV LQAAMQMPPR
     LQPPPLQQMQ QPPRLQQMAP AQQPSITILQ SPPPLQPMQK VRLTLQQPPP LQIKIIPPPL
     QPQPQAVQVQ NQSLSVINVS TSPEAPASPP EQLEVLPEVV QEESPPPQMD VELVSSSPPP
     SLSPQPRCVR SGCENAPIEC KDWDNEYCSN ECVVKHCRDT FMAWIAARSQ GTLATVK