ID   TOXA_COCCA              Reviewed;         548 AA.
AC   Q00357;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Putative HC-toxin efflux carrier TOXA;
GN   Name=TOXA;
OS   Cochliobolus carbonum (Maize leaf spot fungus) (Bipolaris zeicola).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX   NCBI_TaxID=5017 {ECO:0000312|EMBL:AAB36607.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 90305 / SB111 / 2R15;
RX   PubMed=8704997; DOI=10.1099/13500872-142-6-1557;
RA   Pitkin J.W., Panaccione D.G., Walton J.D.;
RT   "A putative cyclic peptide efflux pump encoded by the TOXA gene of the
RT   plant-pathogenic fungus Cochliobolus carbonum.";
RL   Microbiology 142:1557-1565(1996).
CC   -!- FUNCTION: Putative HC-toxin efflux pump with a potential role in self-
CC       protection against and/or secretion of the toxin.
CC       {ECO:0000303|PubMed:8704997}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L48797; AAB36607.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q00357; -.
DR   SMR; Q00357; -.
DR   PHI-base; PHI:60; -.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0019534; F:toxin transmembrane transporter activity; NAS:UniProtKB.
DR   GO; GO:1901998; P:toxin transport; NAS:UniProtKB.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..548
FT                   /note="Putative HC-toxin efflux carrier TOXA"
FT                   /id="PRO_0000173436"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        411..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        444..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        518..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   548 AA;  58045 MW;  410747C172F35482 CRC64;
     MDEQIVSASS NVKDGVEKQP VKDREDVDAN VVPPHSTPSL PKISLISLFS IVMSLGAAAF
     LGALDATVVA VLTPTLAQEF HSVDAVAWYG AIYLLMSGTT QPLFGKLYNE FSPKWLFITC
     LIVLQLGSLV CALARNSPTF IVGRAVAGIG AGGILSGALN IVALIVPLHH RAAFTGMIGA
     LECVALIIGP IIGGAIADNI GWRWCFWINL PIGAAVCAIL LFFFHPPRST YSASGVPRSY
     SEILGNLDYI GAGMIISSLV CLSLALQWGG TKYKWGDGRV VALLVVFGVL FLSASGHQYW
     KGEKALFPTR LLRQRGFLLS LFNGLCFGGV QYAALYYLPT WFQAIKGETR VGAGIQMLPI
     VGAIIGVNIV AGITISFTGR LAPFIVIATV LASVGSGLLY TFTPTKSQAR IIGYQLIYGA
     GSGAGVQQAF IGAQAALDPA DVTYASASVL LMNSMSGVIT LCVCQNLFTN RINALTEVLP
     GVTKETLQSG FAFLRSTLTP AEFGVAIQTF NSAIQDAFLV AIVLSCASVL GWPFLSWASV
     KGQKKMNK