TOXR_PSEAE
ID TOXR_PSEAE Reviewed; 259 AA.
AC P09852;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 08-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Exotoxin A regulatory protein;
GN Name=toxR; Synonyms=regA; OrderedLocusNames=PA0707;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 29260 / PA103;
RX PubMed=3133641; DOI=10.1093/nar/16.12.5699;
RA Hindahl M.S., Frank D.W., Hamood A., Iglewski B.H.;
RT "Characterization of a gene that regulates toxin A synthesis in Pseudomonas
RT aeruginosa.";
RL Nucleic Acids Res. 16:5699-5699(1988).
RN [2]
RP ERRATUM OF PUBMED:3133641, AND SEQUENCE REVISION.
RA Hindahl M.S., Frank D.W., Hamood A., Iglewski B.H.;
RL Nucleic Acids Res. 16:8752-8752(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND CHARACTERIZATION.
RX PubMed=3031589; DOI=10.1093/nar/15.5.2123;
RA Wozniak D.J., Cram D.C., Daniels C.J., Galloway D.R.;
RT "Nucleotide sequence and characterization of toxR: a gene involved in
RT exotoxin A regulation in Pseudomonas aeruginosa.";
RL Nucleic Acids Res. 15:2123-2135(1987).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
RX PubMed=2507519; DOI=10.1128/jb.171.10.5304-5313.1989;
RA Frank D.W., Storey D.G., Hindahl M.S., Iglewski B.H.;
RT "Differential regulation by iron of regA and toxA transcript accumulation
RT in Pseudomonas aeruginosa.";
RL J. Bacteriol. 171:5304-5313(1989).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=2105298; DOI=10.1128/jb.172.2.589-594.1990;
RA Hamood A., Iglewski B.H.;
RT "Expression of the Pseudomonas aeruginosa toxA positive regulatory gene
RT (regA) in Escherichia coli.";
RL J. Bacteriol. 172:589-594(1990).
CC -!- FUNCTION: Positive regulation of toxA gene transcription.
CC {ECO:0000269|PubMed:3031589}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:2105298};
CC Peripheral membrane protein {ECO:0000269|PubMed:2105298}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA02982.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X12366; CAA30927.1; -; Genomic_DNA.
DR EMBL; M31686; AAA02982.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AE004091; AAG04096.1; -; Genomic_DNA.
DR EMBL; M29685; AAA25981.1; -; Genomic_DNA.
DR PIR; A26569; A26569.
DR PIR; D83557; D83557.
DR PIR; S03173; S03173.
DR RefSeq; NP_249398.1; NC_002516.2.
DR RefSeq; WP_010793844.1; NZ_QZGE01000025.1.
DR AlphaFoldDB; P09852; -.
DR SMR; P09852; -.
DR STRING; 287.DR97_1410; -.
DR PaxDb; P09852; -.
DR PRIDE; P09852; -.
DR DNASU; 880684; -.
DR EnsemblBacteria; AAG04096; AAG04096; PA0707.
DR GeneID; 880684; -.
DR KEGG; pae:PA0707; -.
DR PATRIC; fig|208964.12.peg.741; -.
DR PseudoCAP; PA0707; -.
DR HOGENOM; CLU_1115016_0_0_6; -.
DR OMA; GRHYSEP; -.
DR BioCyc; PAER208964:G1FZ6-718-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:PseudoCAP.
DR Gene3D; 3.20.20.450; -; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR Pfam; PF00563; EAL; 1.
DR SUPFAM; SSF141868; SSF141868; 1.
PE 1: Evidence at protein level;
KW Activator; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..259
FT /note="Exotoxin A regulatory protein"
FT /id="PRO_0000072638"
FT CONFLICT 144
FT /note="T -> A (in Ref. 1 and 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 259 AA; 28855 MW; AB44909E2FDE6C68 CRC64;
MTATDRTPPP LKWLCLGNRD ANDGFELFAH GIYARNGALV GSKLSLRERR QRVDLSAFLS
GAPPLLAEAA VKHLLARLLC VHRHNTDLEL LGKNFIPLHA SSLGNAGVCE RILASARQLQ
QHQVELCLLL AIDEQEPASA EYLTSLARLR DSGVRIALHP QRIDTDARQC FAEVDAGLCD
YLGLDARLLA PGPLTRNLRQ RKSIEYLNRL LVAQDIQMLC LNVDNEELHQ QANALPFAFR
HGRHYSEPFQ AWPFSSPAC
