TOXR_VIBPA
ID TOXR_VIBPA Reviewed; 292 AA.
AC Q05938; Q9K309; Q9K310; Q9K314; Q9K349;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2003, sequence version 2.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Cholera toxin homolog transcriptional activator;
GN Name=toxR; OrderedLocusNames=VP0820;
OS Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=223926;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AQ3815;
RX PubMed=8509337; DOI=10.1128/jb.175.12.3844-3855.1993;
RA Lin Z., Kumagai K., Baba K., Mekalanos J.J., Nishibuchi M.;
RT "Vibrio parahaemolyticus has a homolog of the Vibrio cholerae toxRS operon
RT that mediates environmentally induced regulation of the thermostable direct
RT hemolysin gene.";
RL J. Bacteriol. 175:3844-3855(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AN-16000 / Serotype O1:KUT, AN-5034 / Serotype O4:K68, AN-8917,
RC AQ3810 / Serotype O3:K6, AQ4901 / Serotype O3:K6,
RC ATCC BAA-239 / VP81 / Serotype O3:K6, BE98-2062 / Serotype O3:K6,
RC DOH272 / Serotype O3:K6, FIHES98V14-1 / Serotype O3:K6,
RC JKY-VP6 / Serotype O3:K6, U-5474 / Serotype O3:K6, VP108 / Serotype O3:K6,
RC and Y-27669;
RX PubMed=10655349; DOI=10.1128/jcm.38.2.578-585.2000;
RA Matsumoto C., Okuda J., Ishibashi M., Iwanaga M., Garg P., Rammamurthy T.,
RA Wong H.-C., Depaola A., Kim Y.B., Albert M.J., Nishibuchi M.;
RT "Pandemic spread of an O3:K6 clone of Vibrio parahaemolyticus and emergence
RT of related strains evidenced by arbitrarily primed PCR and toxRS sequence
RT analyses.";
RL J. Clin. Microbiol. 38:578-585(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=VPHY191, VPHY197, and VPHY216;
RA Laohaprertthisan V., Chowdhury A., Kongmuang U., Kalnauwakul S.,
RA Ishibashi M., Matsumoto C., Nishibuchi V.;
RT "Prevalence of a pandemic clone and its diversity among Vibrio
RT parahaemolyticus strains isolated from the patients with diarrhea in
RT southern Thailand.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RIMD 2210086;
RA Gonzalez N., Romero J., Moreno C., Torres J., Guzman C.A., Espejo R.T.;
RT "Inferred lineage of pandemic Vibrio parahaemolyticus strains by comparison
RT of their 16S rRNA genes and 16S-23S rRNA spacers.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633;
RX PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
CC -!- FUNCTION: In the presence of ToxS, promotes the expression of the
CC thermostable direct hemolysin 2. May be a global regulator.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; L11929; AAA27576.1; -; Genomic_DNA.
DR EMBL; AB029903; BAA89504.1; -; Genomic_DNA.
DR EMBL; AB029904; BAA89506.1; -; Genomic_DNA.
DR EMBL; AB029905; BAA89508.1; -; Genomic_DNA.
DR EMBL; AB029906; BAA89510.1; -; Genomic_DNA.
DR EMBL; AB029907; BAA89512.1; -; Genomic_DNA.
DR EMBL; AB029908; BAA89514.1; -; Genomic_DNA.
DR EMBL; AB029909; BAA89516.1; -; Genomic_DNA.
DR EMBL; AB029910; BAA89518.1; -; Genomic_DNA.
DR EMBL; AB029911; BAA89520.1; -; Genomic_DNA.
DR EMBL; AB029912; BAA89522.1; -; Genomic_DNA.
DR EMBL; AB029913; BAA89524.1; -; Genomic_DNA.
DR EMBL; AB029914; BAA89526.1; -; Genomic_DNA.
DR EMBL; AB029915; BAA89528.1; -; Genomic_DNA.
DR EMBL; AB063111; BAB79249.1; -; Genomic_DNA.
DR EMBL; AB063112; BAB79251.1; -; Genomic_DNA.
DR EMBL; AB063113; BAB79253.1; -; Genomic_DNA.
DR EMBL; AY527397; AAS55476.1; -; Genomic_DNA.
DR EMBL; BA000031; BAC59083.1; -; Genomic_DNA.
DR PIR; A47125; A47125.
DR RefSeq; NP_797199.1; NC_004603.1.
DR RefSeq; WP_005478489.1; NC_004603.1.
DR AlphaFoldDB; Q05938; -.
DR SMR; Q05938; -.
DR STRING; 223926.28805806; -.
DR EnsemblBacteria; BAC59083; BAC59083; BAC59083.
DR GeneID; 1188317; -.
DR KEGG; vpa:VP0820; -.
DR PATRIC; fig|223926.6.peg.777; -.
DR eggNOG; COG3710; Bacteria.
DR HOGENOM; CLU_085388_0_0_6; -.
DR OMA; HEFVWRE; -.
DR Proteomes; UP000002493; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 4: Predicted;
KW Activator; Cell membrane; DNA-binding; Membrane; Reference proteome;
KW Transcription; Transcription regulation; Transmembrane;
KW Transmembrane helix; Two-component regulatory system.
FT CHAIN 1..292
FT /note="Cholera toxin homolog transcriptional activator"
FT /id="PRO_0000081347"
FT TOPO_DOM 1..180
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..292
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT DNA_BIND 6..109
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT REGION 119..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 134
FT /note="N -> I (in strain: DOH272 and AQ4901)"
FT VARIANT 138
FT /note="A -> T (in strain: AQ3810 and U-5474)"
FT VARIANT 148..150
FT /note="SLA -> PLT (in strain: DOH272 and AQ4901)"
FT VARIANT 152
FT /note="T -> P (in strain: Y-27669, AN-8917 and RIMD
FT 2210086)"
FT VARIANT 152
FT /note="T -> S (in strain: AQ3815)"
FT VARIANT 169
FT /note="P -> H (in strain: AQ3815)"
SQ SEQUENCE 292 AA; 32578 MW; 5CB73E0457C523B8 CRC64;
MTNIGTKFLL AQRFTFDPNS NSLADQQSGN EVVRLGSNES RILLMLAERP NEVLTRNELH
EFVWREQGFE VDDSSLTQAI STLRKMLKDS TKSPEFVKTV PKRGYQLICT VERLSPLSSD
SSSIEVEEPA SDNNDASANE VETIVEPSLA TTSDAIVEPE APVVPEKAPV ASAVNPWIPR
VILFLALLLP ICVLLFTNPA ESQFRQIGEY QNVPVMTPVN HPQINNWLPS IEQCIERYVK
HHAEDSLPVE VIATGGQNNQ LILNYIHDSN HSYENVTLRI FAGQNDPTDI CK
