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TOXS_VIBCH
ID   TOXS_VIBCH              Reviewed;         173 AA.
AC   P24003; Q9KTC0;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Transmembrane regulatory protein ToxS;
GN   Name=toxS; OrderedLocusNames=VC_0983;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INTERACTION WITH TOXR.
RX   PubMed=1898871; DOI=10.1016/0092-8674(91)90206-e;
RA   DiRita V.J., Mekalanos J.J.;
RT   "Periplasmic interaction between two membrane regulatory proteins, ToxR and
RT   ToxS, results in signal transduction and transcriptional activation.";
RL   Cell 64:29-37(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Interacts with ToxR and stimulates its activity.
CC       {ECO:0000269|PubMed:1898871}.
CC   -!- SUBUNIT: Interacts with the C-terminal periplasmic domain of ToxR,
CC       possibly by binding and stabilizing spontaneously forming ToxR dimers.
CC       {ECO:0000269|PubMed:1898871}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein;
CC       Periplasmic side.
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DR   EMBL; M62761; AAA63559.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF94144.1; -; Genomic_DNA.
DR   PIR; B38435; B38435.
DR   RefSeq; NP_230629.1; NC_002505.1.
DR   RefSeq; WP_001181145.1; NZ_LT906614.1.
DR   AlphaFoldDB; P24003; -.
DR   STRING; 243277.VC_0983; -.
DR   DNASU; 2614236; -.
DR   EnsemblBacteria; AAF94144; AAF94144; VC_0983.
DR   GeneID; 57739670; -.
DR   KEGG; vch:VC_0983; -.
DR   PATRIC; fig|243277.26.peg.936; -.
DR   eggNOG; ENOG5031MTT; Bacteria.
DR   HOGENOM; CLU_127087_0_0_6; -.
DR   OMA; GWLYWGS; -.
DR   BioCyc; VCHO:VC0983-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR035288; ToxS.
DR   Pfam; PF17323; ToxS; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..173
FT                   /note="Transmembrane regulatory protein ToxS"
FT                   /id="PRO_0000072639"
FT   TOPO_DOM        1..5
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..173
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        172
FT                   /note="N -> K (in Ref. 1; AAA63559)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   173 AA;  19731 MW;  D38246C48A5ED7ED CRC64;
     MQNRHIAMGI LLLSLLLSSW LYWGSDFKLE QVLTSREWQS KMVSLIKTNS NRPAMGPLSR
     VDVTSNVKYL PNGTYLRVSI VKLFSDDNSA ESVINISEFG EWDISDNYLL VTPVEFKDIS
     SNQSKDFTDE QLQLITQLFK MDAQQSRRVD IVNERTILFT SLSHGSTVLF SNS
 
 
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