ID   TOXS_VIBPA              Reviewed;         171 AA.
AC   Q05939; Q8VL53; Q9K2V2;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Transmembrane regulatory protein ToxS;
GN   Name=toxS; OrderedLocusNames=VP0819;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AQ3815;
RX   PubMed=8509337; DOI=10.1128/jb.175.12.3844-3855.1993;
RA   Lin Z., Kumagai K., Baba K., Mekalanos J.J., Nishibuchi M.;
RT   "Vibrio parahaemolyticus has a homolog of the Vibrio cholerae toxRS operon
RT   that mediates environmentally induced regulation of the thermostable direct
RT   hemolysin gene.";
RL   J. Bacteriol. 175:3844-3855(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-166.
RC   STRAIN=VPHY191, VPHY197, and VPHY216;
RA   Laohaprertthisan V., Chowdhury A., Kongmuang U., Kalnauwakul S.,
RA   Ishibashi M., Matsumoto C., Nishibuchi V.;
RT   "Prevalence of a pandemic clone and its diversity among Vibrio
RT   parahaemolyticus strains isolated from the patients with diarrhea in
RT   southern Thailand.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-151.
RC   STRAIN=AN-16000 / Serotype O1:KUT, AN-5034 / Serotype O4:K68, AN-8917,
RC   AQ3810 / Serotype O3:K6, AQ4901 / Serotype O3:K6,
RC   ATCC BAA-239 / VP81 / Serotype O3:K6, BE98-2062 / Serotype O3:K6,
RC   DOH272 / Serotype O3:K6, FIHES98V14-1 / Serotype O3:K6,
RC   JKY-VP6 / Serotype O3:K6, U-5474 / Serotype O3:K6, VP108 / Serotype O3:K6,
RC   and Y-27669;
RX   PubMed=10655349; DOI=10.1128/jcm.38.2.578-585.2000;
RA   Matsumoto C., Okuda J., Ishibashi M., Iwanaga M., Garg P., Rammamurthy T.,
RA   Wong H.-C., Depaola A., Kim Y.B., Albert M.J., Nishibuchi M.;
RT   "Pandemic spread of an O3:K6 clone of Vibrio parahaemolyticus and emergence
RT   of related strains evidenced by arbitrarily primed PCR and toxRS sequence
RT   analyses.";
RL   J. Clin. Microbiol. 38:578-585(2000).
CC   -!- FUNCTION: Interacts with ToxR and stimulates its activity.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the C-terminal periplasmic domain of ToxR,
CC       possibly by binding and stabilizing spontaneously forming ToxR dimers.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein;
CC       Periplasmic side.
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DR   EMBL; L11929; AAA27577.1; -; Genomic_DNA.
DR   EMBL; BA000031; BAC59082.1; -; Genomic_DNA.
DR   EMBL; AB063111; BAB79250.1; -; Genomic_DNA.
DR   EMBL; AB063112; BAB79252.1; -; Genomic_DNA.
DR   EMBL; AB063113; BAB79254.1; -; Genomic_DNA.
DR   EMBL; AB029903; BAA89505.1; -; Genomic_DNA.
DR   EMBL; AB029904; BAA89507.1; -; Genomic_DNA.
DR   EMBL; AB029905; BAA89509.1; -; Genomic_DNA.
DR   EMBL; AB029906; BAA89511.1; -; Genomic_DNA.
DR   EMBL; AB029907; BAA89513.1; -; Genomic_DNA.
DR   EMBL; AB029908; BAA89515.1; -; Genomic_DNA.
DR   EMBL; AB029909; BAA89517.1; -; Genomic_DNA.
DR   EMBL; AB029910; BAA89519.1; -; Genomic_DNA.
DR   EMBL; AB029911; BAA89521.1; -; Genomic_DNA.
DR   EMBL; AB029912; BAA89523.1; -; Genomic_DNA.
DR   EMBL; AB029913; BAA89525.1; -; Genomic_DNA.
DR   EMBL; AB029914; BAA89527.1; -; Genomic_DNA.
DR   EMBL; AB029915; BAA89529.1; -; Genomic_DNA.
DR   PIR; B47125; B47125.
DR   RefSeq; NP_797198.1; NC_004603.1.
DR   RefSeq; WP_005454545.1; NC_004603.1.
DR   AlphaFoldDB; Q05939; -.
DR   STRING; 223926.28805805; -.
DR   EnsemblBacteria; BAC59082; BAC59082; BAC59082.
DR   GeneID; 1188316; -.
DR   KEGG; vpa:VP0819; -.
DR   PATRIC; fig|223926.6.peg.776; -.
DR   eggNOG; ENOG5031MTT; Bacteria.
DR   HOGENOM; CLU_127087_0_0_6; -.
DR   OMA; GWLYWGS; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR035288; ToxS.
DR   Pfam; PF17323; ToxS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..171
FT                   /note="Transmembrane regulatory protein ToxS"
FT                   /id="PRO_0000072640"
FT   TOPO_DOM        1..2
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..171
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   171 AA;  19201 MW;  8F6291338C89FE7C CRC64;
     MKIKVASAVL AVSILFSGWL YWGSDLKVEQ VLTSNEWQST MVTVITDNLP DDTVGPLRRV
     NVESNVKYLP NGDYIRVANI KLFAQGSTAE STINISEKGR WEVSDNYLLV SPSEFKDISS
     SQSKDFSEAQ LRLITQIFKL DAEQSRRIDV VNEKTLLLTS LNHGSTVLFR N