ID   BTUB_PHOPR              Reviewed;         606 AA.
AC   Q6LLU3;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Vitamin B12 transporter BtuB {ECO:0000255|HAMAP-Rule:MF_01531};
DE   AltName: Full=Cobalamin receptor {ECO:0000255|HAMAP-Rule:MF_01531};
DE   AltName: Full=Outer membrane cobalamin translocator {ECO:0000255|HAMAP-Rule:MF_01531};
DE   Flags: Precursor;
GN   Name=btuB {ECO:0000255|HAMAP-Rule:MF_01531}; OrderedLocusNames=PBPRA3464;
OS   Photobacterium profundum (strain SS9).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Photobacterium.
OX   NCBI_TaxID=298386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1253 / SS9;
RX   PubMed=15746425; DOI=10.1126/science.1103341;
RA   Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M.,
RA   Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C.,
RA   Bartlett D.H., Valle G.;
RT   "Life at depth: Photobacterium profundum genome sequence and expression
RT   analysis.";
RL   Science 307:1459-1461(2005).
CC   -!- FUNCTION: Involved in the active translocation of vitamin B12
CC       (cyanocobalamin) across the outer membrane to the periplasmic space. It
CC       derives its energy for transport by interacting with the trans-
CC       periplasmic membrane protein TonB. {ECO:0000255|HAMAP-Rule:MF_01531}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01531}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01531}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family. BtuB (TC
CC       1.B.14.3.1) subfamily. {ECO:0000255|HAMAP-Rule:MF_01531}.
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DR   EMBL; CR378674; CAG21735.1; -; Genomic_DNA.
DR   RefSeq; WP_011219976.1; NC_006370.1.
DR   AlphaFoldDB; Q6LLU3; -.
DR   SMR; Q6LLU3; -.
DR   STRING; 298386.PBPRA3464; -.
DR   EnsemblBacteria; CAG21735; CAG21735; PBPRA3464.
DR   KEGG; ppr:PBPRA3464; -.
DR   eggNOG; COG4206; Bacteria.
DR   HOGENOM; CLU_008287_18_5_6; -.
DR   OMA; GHWAVNA; -.
DR   OrthoDB; 71288at2; -.
DR   Proteomes; UP000000593; Chromosome 1.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   HAMAP; MF_01531; BtuB; 1.
DR   InterPro; IPR010101; B12_transptr_BtuB.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Reference proteome;
KW   Signal; TonB box; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01531"
FT   CHAIN           22..606
FT                   /note="Vitamin B12 transporter BtuB"
FT                   /id="PRO_0000003485"
FT   MOTIF           28..35
FT                   /note="TonB box"
FT   MOTIF           589..606
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   606 AA;  66298 MW;  226F389FB08B94C0 CRC64;
     MKKTLLAVAL APLCLPSQVF AADESSNDVM VVTANRFEQP IKNVIAPISV VTKEEIDAIQ
     AKSIAEVLRR LPGVQVVSGG YGQATEVYVR GTTSRHLLVM INGVRIGSAT LGSADFSQIP
     LTGIERIELI RGSRAALYGS DAIGGVLNII TAYQPGESVA EVTAGGGSDG FYQLGGSVAG
     GLGESGWGKI ALKTEGADGF SARKEPFEQD DDGFKNSNVV AEVGTHVGDH WKLSLQGYYH
     DGESDYDDSY GAPHAQSESS LFNIAAKAGY SNDKLDSQFT VAQNQDENRN FNDVSSGSKI
     KTERTVANWQ NHYQLTDGLE LGGGLEWYRD SVSNTGTQYA EDERDNTAVY LTSIYRISDW
     QFEGSVRTDD NDSYGTNNTW QLATAYNITS ELKVSANAGT GFKAPTFNDL YWPDSGNPNL
     KPEESKNYEI SLSGTHQLLD WSITGYQSEI DQLIAWAPKD ASNPSGDWIP MNVDEAEIQG
     IELTAGFATG MLYHDVSYDY LDAKDKGLDK QLIRRSKDSA KWNVSYLAEQ WQLDVSAIYK
     GTSYDDAANT KKLDAYTLVD IAASYFVTDN LSVRGRIANL FDKDYVAKET YNVQERSYYA
     TATYKF