ID   TP1A_RANDY              Reviewed;          14 AA.
AC   P0C5X6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   17-JUN-2020, entry version 14.
DE   RecName: Full=Temporin-1DYa;
OS   Rana dybowskii (Dybovsky's frog) (Korean brown frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=71582;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT GLY-14, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Skin secretion;
RX   PubMed=17688900; DOI=10.1016/j.toxicon.2007.06.023;
RA   Conlon J.M., Kolodziejek J., Nowotny N., Leprince J., Vaudry H., Coquet L.,
RA   Jouenne T., Iwamuro S.;
RT   "Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families
RT   isolated from the skin of the Japanese brown frog, Rana dybowskii.";
RL   Toxicon 50:746-756(2007).
CC   -!- FUNCTION: Antimicrobial peptide. Active against the Gram-positive
CC       bacterium S.aureus (MIC>60 uM) and the Gram-negative bacterium E.coli
CC       (MIC>60 uM). {ECO:0000269|PubMed:17688900}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- MASS SPECTROMETRY: Mass=1403.8; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17688900};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Temporin subfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Temporin-1DYa"
FT                   /id="PRO_0000311604"
FT   MOD_RES         14
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:17688900"
SQ   SEQUENCE   14 AA;  1406 MW;  9D0EAF727CACF3C5 CRC64;
     FIGPIISALA SLFG