TP3_AMOMA
ID TP3_AMOMA Reviewed; 61 AA.
AC E1B248;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 25-MAY-2022, entry version 23.
DE RecName: Full=Temporin-MT3 {ECO:0000303|PubMed:24601776};
DE Flags: Precursor;
OS Amolops mantzorum (Sichuan torrent frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Amolops.
OX NCBI_TaxID=167930 {ECO:0000312|EMBL:ADM34281.1};
RN [1] {ECO:0000312|EMBL:ADM34281.1}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 47-59, SUBCELLULAR
RP LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, AND AMIDATION AT LEU-59.
RC TISSUE=Skin {ECO:0000303|PubMed:24601776}, and
RC Skin secretion {ECO:0000303|PubMed:24601776};
RX PubMed=24601776; DOI=10.2108/zsj.31.143;
RA Hu Y., Yu Z., Xu S., Hu Y., Guo C., Li F., Li J., Liu J., Wang H.;
RT "Peptidomic analysis of antimicrobial peptides in skin secretions of
RT Amolops mantzorum.";
RL Zool. Sci. 31:143-151(2014).
CC -!- FUNCTION: Antimicrobial peptide. {ECO:0000250|UniProtKB:P82848}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255,
CC ECO:0000269|PubMed:24601776}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000305|PubMed:24601776}.
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Temporin subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HQ128623; ADM34281.1; -; mRNA.
DR AlphaFoldDB; E1B248; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR Pfam; PF03032; FSAP_sig_propep; 1.
PE 1: Evidence at protein level;
KW Amidation; Amphibian defense peptide; Antimicrobial;
KW Cleavage on pair of basic residues; Direct protein sequencing; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..44
FT /note="Removed in mature form"
FT /evidence="ECO:0000305|PubMed:24601776"
FT /id="PRO_0000440088"
FT PEPTIDE 47..59
FT /note="Temporin-MT3"
FT /evidence="ECO:0000269|PubMed:24601776"
FT /id="PRO_0000440089"
FT MOD_RES 59
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:24601776"
SQ SEQUENCE 61 AA; 7059 MW; 576D76724380A91F CRC64;
MFTLKKPLLL LFFLGTINLS LCEQERNAEE ERRDEPDERN AEVEKRFLPI VGKLLSGLLG
K