TP4AA_DICDI
ID TP4AA_DICDI Reviewed; 166 AA.
AC Q54DU9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Probable protein tyrosine phosphatase type IVA A;
DE EC=3.1.3.48;
DE Flags: Precursor;
GN ORFNames=DDB_G0292024;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000187; EAL61368.1; -; Genomic_DNA.
DR RefSeq; XP_629773.1; XM_629771.1.
DR AlphaFoldDB; Q54DU9; -.
DR SMR; Q54DU9; -.
DR STRING; 44689.DDB0238561; -.
DR PaxDb; Q54DU9; -.
DR EnsemblProtists; EAL61368; EAL61368; DDB_G0292024.
DR GeneID; 8628449; -.
DR KEGG; ddi:DDB_G0292024; -.
DR dictyBase; DDB_G0292024; -.
DR eggNOG; KOG2836; Eukaryota.
DR HOGENOM; CLU_099263_2_0_1; -.
DR InParanoid; Q54DU9; -.
DR OMA; NGQKNSC; -.
DR PhylomeDB; Q54DU9; -.
DR Reactome; R-DDI-8873719; RAB geranylgeranylation.
DR PRO; PR:Q54DU9; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR022778; CDKN3.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR Pfam; PF05706; CDKN3; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Hydrolase; Lipoprotein; Membrane; Methylation; Prenylation;
KW Protein phosphatase; Reference proteome.
FT CHAIN 1..163
FT /note="Probable protein tyrosine phosphatase type IVA A"
FT /id="PRO_0000329025"
FT PROPEP 164..166
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000396656"
FT DOMAIN 10..164
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT ACT_SITE 75
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 107
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT BINDING 108..113
FT /ligand="phosphate"
FT /ligand_id="ChEBI:CHEBI:43474"
FT /evidence="ECO:0000250"
FT BINDING 113
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT MOD_RES 163
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 163
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250"
FT DISULFID 52..107
FT /evidence="ECO:0000250"
SQ SEQUENCE 166 AA; 18422 MW; B9A1CE094E6AB73D CRC64;
MTGIRSALPN PASLVESSTH RFLIFDAPND DNLPLYINEL KKYNVSHLVR ACDPTYSTEP
LQAIGIQVHD MPFADGGSPP DAVVNNWIKI LGESYKKDSK ETIGIHCVAG LGRAPVLVAI
ALIEGGMNPL QAVEYIRERR RGSINIKQIQ YLKNYKSKKK SSCRIM
