ID   TP8L1_BOVIN             Reviewed;         186 AA.
AC   A5PK29;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 1;
DE            Short=TIPE1 {ECO:0000250|UniProtKB:Q8K288};
DE            Short=TNF alpha-induced protein 8-like protein 1;
DE            Short=TNFAIP8-like protein 1;
GN   Name=TNFAIP8L1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of mTOR activity.
CC       {ECO:0000250|UniProtKB:Q8K288}.
CC   -!- SUBUNIT: Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind
CC       FBXW5 increasing TSC2 stability by preventing its ubiquitination.
CC       {ECO:0000250|UniProtKB:Q8K288}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K288}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. {ECO:0000305}.
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DR   EMBL; BC142331; AAI42332.1; -; mRNA.
DR   RefSeq; NP_001096740.1; NM_001103270.2.
DR   RefSeq; XP_010805286.1; XM_010806984.2.
DR   AlphaFoldDB; A5PK29; -.
DR   SMR; A5PK29; -.
DR   STRING; 9913.ENSBTAP00000047526; -.
DR   PaxDb; A5PK29; -.
DR   PRIDE; A5PK29; -.
DR   Ensembl; ENSBTAT00000055062; ENSBTAP00000047526; ENSBTAG00000037765.
DR   GeneID; 531850; -.
DR   KEGG; bta:531850; -.
DR   CTD; 126282; -.
DR   VEuPathDB; HostDB:ENSBTAG00000037765; -.
DR   VGNC; VGNC:36158; TNFAIP8L1.
DR   eggNOG; ENOG502S00N; Eukaryota.
DR   GeneTree; ENSGT00390000003488; -.
DR   HOGENOM; CLU_085918_1_0_1; -.
DR   InParanoid; A5PK29; -.
DR   OMA; HQAVNTH; -.
DR   OrthoDB; 1284744at2759; -.
DR   TreeFam; TF323415; -.
DR   Reactome; R-BTA-1483255; PI Metabolism.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000037765; Expressed in thymus and 106 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..186
FT                   /note="Tumor necrosis factor alpha-induced protein 8-like
FT                   protein 1"
FT                   /id="PRO_0000331429"
SQ   SEQUENCE   186 AA;  20880 MW;  91E7376168DF6B3A CRC64;
     MDTFSTKSLA LQAQKKLLSK MASRAVASAF IDDTSSEVLD ELYRATKEFT RSRKEAQKLV
     KNLVKVAVKL GVLLRAGQLG AEELARLQRL RQQARRLAMT AVSFHQVDFT FDRRVLATTL
     LECRDLLHQA AGAHLTAKSH GRINHVFGHL ADCDFLAALY SPAEPYRSHL RRICDGLTRM
     LDEDSI